Names & Taxonomy
- Uniprot ID:
- Q15648
- Entry Name:
- MED1_HUMAN
- Status:
- reviewed
- Protein Names:
- Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A)
- Gene Names:
- MED1 ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2
- Gene Names Primary:
- MED1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1581
- Sequence:
- MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLPPEKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFHDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNNQADTVDFSIISVAGKALAPADLMEHHSGSQGPLLTTGDLGKEKTQKRVKEGNGTSNSTLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSAGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPLDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).
- Gene Ontology Go:
- chromatin
mediator complex
membrane
nucleolus
nucleoplasm
nucleus
protein-DNA complex
ubiquitin ligase complex
chromatin binding
chromatin DNA binding
core promoter binding
estrogen receptor binding
LBD domain binding
ligand-dependent nuclear receptor binding
ligand-dependent nuclear receptor transcription coactivator activity
mediator complex binding
nuclear hormone receptor binding
peroxisome proliferator activated receptor binding
receptor activity
retinoic acid receptor binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription cofactor activity
RNA polymerase II transcription factor activity, sequence-specific DNA binding
thyroid hormone receptor binding
thyroid hormone receptor coactivator activity
transcription coactivator activity
transcription cofactor activity
transcription factor binding
ubiquitin protein ligase activity
vitamin D receptor binding
androgen biosynthetic process
androgen receptor signaling pathway
angiogenesis
brain development
cell morphogenesis
cellular lipid metabolic process
cellular response to epidermal growth factor stimulus
cellular response to hepatocyte growth factor stimulus
cellular response to steroid hormone stimulus
cellular response to thyroid hormone stimulus
embryonic heart tube development
embryonic hemopoiesis
embryonic hindlimb morphogenesis
embryonic placenta development
enucleate erythrocyte development
epithelial cell proliferation involved in mammary gland duct elongation
ERK1 and ERK2 cascade
erythrocyte development
fat cell differentiation
gene expression
intracellular steroid hormone receptor signaling pathway
keratinocyte differentiation
lactation
lens development in camera-type eye
liver development
mammary gland branching involved in pregnancy
mammary gland branching involved in thelarche
megakaryocyte development
monocyte differentiation
mRNA transcription from RNA polymerase II promoter
negative regulation of apoptotic process
negative regulation of keratinocyte proliferation
negative regulation of neuron differentiation
negative regulation of transcription from RNA polymerase II promoter
organ regeneration
peroxisome proliferator activated receptor signaling pathway
positive regulation of erythrocyte differentiation
positive regulation of G0 to G1 transition
positive regulation of gene expression
positive regulation of hepatocyte proliferation
positive regulation of interferon-gamma-mediated signaling pathway
positive regulation of intracellular estrogen receptor signaling pathway
positive regulation of keratinocyte differentiation
positive regulation of mammary gland epithelial cell proliferation
positive regulation of protein import into nucleus, translocation
positive regulation of receptor activity
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
regulation of cell cycle
regulation of RNA biosynthetic process
regulation of transcription from RNA polymerase I promoter
regulation of vitamin D receptor signaling pathway
retinal pigment epithelium development
small molecule metabolic process
thyroid hormone generation
thyroid hormone mediated signaling pathway
transcription initiation from RNA polymerase II promoter
ventricular trabecula myocardium morphogenesis - Gene Ontology Biological Process:
- androgen biosynthetic process
androgen receptor signaling pathway
angiogenesis
brain development
cell morphogenesis
cellular lipid metabolic process
cellular response to epidermal growth factor stimulus
cellular response to hepatocyte growth factor stimulus
cellular response to steroid hormone stimulus
cellular response to thyroid hormone stimulus
embryonic heart tube development
embryonic hemopoiesis
embryonic hindlimb morphogenesis
embryonic placenta development
enucleate erythrocyte development
epithelial cell proliferation involved in mammary gland duct elongation
ERK1 and ERK2 cascade
erythrocyte development
fat cell differentiation
gene expression
intracellular steroid hormone receptor signaling pathway
keratinocyte differentiation
lactation
lens development in camera-type eye
liver development
mammary gland branching involved in pregnancy
mammary gland branching involved in thelarche
megakaryocyte development
monocyte differentiation
mRNA transcription from RNA polymerase II promoter
negative regulation of apoptotic process
negative regulation of keratinocyte proliferation
negative regulation of neuron differentiation
negative regulation of transcription from RNA polymerase II promoter
organ regeneration
peroxisome proliferator activated receptor signaling pathway
positive regulation of erythrocyte differentiation
positive regulation of G0 to G1 transition
positive regulation of gene expression
positive regulation of hepatocyte proliferation
positive regulation of interferon-gamma-mediated signaling pathway
positive regulation of intracellular estrogen receptor signaling pathway
positive regulation of keratinocyte differentiation
positive regulation of mammary gland epithelial cell proliferation
positive regulation of protein import into nucleus, translocation
positive regulation of receptor activity
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of cell cycle
regulation of RNA biosynthetic process
regulation of transcription from RNA polymerase I promoter
regulation of vitamin D receptor signaling pathway
retinal pigment epithelium development
small molecule metabolic process
thyroid hormone generation
thyroid hormone mediated signaling pathway
transcription initiation from RNA polymerase II promoter
ventricular trabecula myocardium morphogenesis - Gene Ontology Molecular Function:
- chromatin binding
chromatin DNA binding
core promoter binding
estrogen receptor binding
LBD domain binding
ligand-dependent nuclear receptor binding
ligand-dependent nuclear receptor transcription coactivator activity
mediator complex binding
nuclear hormone receptor binding
peroxisome proliferator activated receptor binding
receptor activity
retinoic acid receptor binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription cofactor activity
RNA polymerase II transcription factor activity, sequence-specific DNA binding
thyroid hormone receptor binding
thyroid hormone receptor coactivator activity
transcription coactivator activity
transcription cofactor activity
transcription factor binding
ubiquitin protein ligase activity
vitamin D receptor binding - Gene Ontology Cellular Component:
- chromatin
mediator complex
membrane
nucleolus
nucleoplasm
nucleus
protein-DNA complex
ubiquitin ligase complex - Keywords:
- 3D-structure
Acetylation
Activator
Alternative splicing
Complete proteome
DNA-binding
Direct protein sequencing
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transcription
Transcription regulation - Interacts With:
- O43513; P10276; P10827
Publication
- PubMed ID:
- 9444950 9653119 15489334 10235267 10733574 10235266 7776974 10024883 10406464 10478845 10770935 11303023 12218053 12037571 11867769 12034878 12556447 14636573 15471764 15175163 15340084 15989967 16314496 17081983 16574658 17000779 16964243 17525332 18691976 18669648 19413330 19369195 19786558 19690332 19608861 20068231 21269460 21406692 24245781 24275569