Names & Taxonomy
- Uniprot ID:
- Q15102
- Entry Name:
- PA1B3_HUMAN
- Status:
- reviewed
- Protein Names:
- Platelet-activating factor acetylhydrolase IB subunit gamma (EC 3.1.1.47) (PAF acetylhydrolase 29 kDa subunit) (PAF-AH 29 kDa subunit) (PAF-AH subunit gamma) (PAFAH subunit gamma)
- Gene Names:
- PAFAH1B3 PAFAHG
- Gene Names Primary:
- PAFAH1B3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 231
- Sequence:
- MSGEENPASKPTPVQDVQGDGRWMSLHHRFVADSKDKEPEVVFIGDSLVQLMHQCEIWRELFSPLHALNFGIGGDGTQHVLWRLENGELEHIRPKIVVVWVGTNNHGHTAEQVTGGIKAIVQLVNERQPQARVVVLGLLPRGQHPNPLREKNRQVNELVRAALAGHPRAHFLDADPGFVHSDGTISHHDMYDYLHLSRLGYTPVCRALHSLLLRLLAQDQGQGAPLLEPAP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain.
- Catalytic Activity:
- 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H(2)O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.
- Active Site:
- ACT_SITE 47 47
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
membrane
1-alkyl-2-acetylglycerophosphocholine esterase activity
identical protein binding
platelet-activating factor acetyltransferase activity
brain development
lipid catabolic process
lipid metabolic process
nervous system development
spermatogenesis - Gene Ontology Biological Process:
- brain development
lipid catabolic process
lipid metabolic process
nervous system development
spermatogenesis - Gene Ontology Molecular Function:
- 1-alkyl-2-acetylglycerophosphocholine esterase activity
identical protein binding
platelet-activating factor acetyltransferase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
membrane - Keywords:
- Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Hydrolase
Lipid degradation
Lipid metabolism
Polymorphism
Reference proteome - Interacts With:
- Itself; Q8TBB1