Names & Taxonomy
- Uniprot ID:
- P62937
- Entry Name:
- PPIA_HUMAN
- Status:
- reviewed
- Protein Names:
- Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed]
- Gene Names:
- PPIA CYPA
- Gene Names Primary:
- PPIA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 165
- Sequence:
- MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQLE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
- Catalytic Activity:
- Peptidylproline (omega=180) = peptidylproline (omega=0).
- Enzyme Regulation:
- ENZYME REGULATION: Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.
- Cross Reference Drug Bank:
- DB00091 DB00172
- Gene Ontology Go:
- cytosol
extracellular exosome
extracellular region
extracellular space
focal adhesion
membrane
nucleus
peptide binding
peptidyl-prolyl cis-trans isomerase activity
poly(A) RNA binding
unfolded protein binding
virion binding
blood coagulation
entry into host cell
establishment of integrated proviral latency
leukocyte migration
lipid particle organization
platelet activation
platelet degranulation
positive regulation of protein secretion
positive regulation of viral genome replication
protein folding
protein peptidyl-prolyl isomerization
regulation of viral genome replication
RNA-dependent DNA replication
uncoating of virus
viral life cycle
viral process
viral release from host cell
virion assembly - Gene Ontology Biological Process:
- blood coagulation
entry into host cell
establishment of integrated proviral latency
leukocyte migration
lipid particle organization
platelet activation
platelet degranulation
positive regulation of protein secretion
positive regulation of viral genome replication
protein folding
protein peptidyl-prolyl isomerization
regulation of viral genome replication
RNA-dependent DNA replication
uncoating of virus
viral life cycle
viral process
viral release from host cell
virion assembly - Gene Ontology Molecular Function:
- peptide binding
peptidyl-prolyl cis-trans isomerase activity
poly(A) RNA binding
unfolded protein binding
virion binding - Gene Ontology Cellular Component:
- cytosol
extracellular exosome
extracellular region
extracellular space
focal adhesion
membrane
nucleus - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Cyclosporin
Cytoplasm
Direct protein sequencing
Glycoprotein
Host-virus interaction
Isomerase
Isopeptide bond
Phosphoprotein
Reference proteome
Rotamase
Secreted
Ubl conjugation - Interacts With:
- Q99IB8; Q72497; Q8TBB1; Q16849; O00267