Names & Taxonomy
- Uniprot ID:
- P60201
- Entry Name:
- MYPR_HUMAN
- Status:
- reviewed
- Protein Names:
- Myelin proteolipid protein (PLP) (Lipophilin)
- Gene Names:
- PLP1 PLP
- Gene Names Primary:
- PLP1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 277
- Sequence:
- MGLLECCARCLVGAPFASLVATGLCFFGVALFCGCGHEALTGTEKLIETYFSKNYQDYEYLINVIHAFQYVIYGTASFFFLYGALLLAEGFYTTGAVRQIFGDYKTTICGKGLSATVTGGQKGRGSRGQHQAHSLERVCHCLGKWLGHPDKFVGITYALTVVWLLVFACSAVPVYIYFNTWTTCQSIAFPSKTSASIGSLCADARMYGVLPWNAFPGKVCGSNLLSICKTAEFQMTFHLFIAAFVGAAATLVSLLTFMIAATYNFAVLKLMGRGTKF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.
- Gene Ontology Go:
- integral component of membrane
myelin sheath
plasma membrane
structural constituent of myelin sheath
structural molecule activity
astrocyte development
axon development
axon ensheathment
cell maturation
central nervous system myelination
inflammatory response
integrin-mediated signaling pathway
long-chain fatty acid biosynthetic process
positive regulation of gene expression
substantia nigra development
synaptic transmission - Gene Ontology Biological Process:
- astrocyte development
axon development
axon ensheathment
cell maturation
central nervous system myelination
inflammatory response
integrin-mediated signaling pathway
long-chain fatty acid biosynthetic process
positive regulation of gene expression
substantia nigra development
synaptic transmission - Gene Ontology Molecular Function:
- structural constituent of myelin sheath
structural molecule activity - Gene Ontology Cellular Component:
- integral component of membrane
myelin sheath
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Hereditary spastic paraplegia
Leukodystrophy
Lipoprotein
Membrane
Neurodegeneration
Palmitate
Phosphoprotein
Reference proteome
Transmembrane
Transmembrane helix - Interacts With:
- Q16849-3
Publication
- PubMed ID:
- 3467339 2441695 2479017 15772651 15489334 4041237 2449536 1711121 2773936 2480601 1708672 1707231 1715570 1376966 1384324 7684886 7679906 7683951 8037216 8012387 7522741 7539213 7573159 7541731 7531827 8956049 8780101 8909455 9143933 9008538 9482656 9489796 9788732 9747038 9633722 10417279 9934976 9894878 10319897 10425042 11093273 11786921 15450775 15712223 17438221 24103481