Names & Taxonomy
- Uniprot ID:
- P52209
- Entry Name:
- 6PGD_HUMAN
- Status:
- reviewed
- Protein Names:
- 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44)
- Gene Names:
- PGD PGDH
- Gene Names Primary:
- PGD
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 483
- Sequence:
- MAQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKEMVSKLKKPRRIILLVKAGQAVDDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKGILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKTIFQGIAAKVGTGEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANILKFQDTDGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQASKKLKGPQKFQFDGDKKSFLEDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVENCQDSWRRAVSTGVQAGIPMPCFTTALSFYDGYRHEMLPASLIQAQRDYFGAHTYELLAKPGQFIHTNWTGHGGTVSSSSYNA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
- Pathway:
- Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.
- Catalytic Activity:
- 6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH.
- Active Site:
- ACT_SITE 184 184 Proton acceptor.
- Cross Reference Drug Bank:
- DB00851 DB00695 DB00789 DB00920 DB00814 DB00563 DB00867
- Gene Ontology Go:
- cytosol
extracellular exosome
nucleus
phosphogluconate dehydrogenase (decarboxylating) activity
carbohydrate metabolic process
D-gluconate metabolic process
oxidation-reduction process
pentose biosynthetic process
pentose-phosphate shunt
pentose-phosphate shunt, oxidative branch
small molecule metabolic process - Gene Ontology Biological Process:
- carbohydrate metabolic process
D-gluconate metabolic process
oxidation-reduction process
pentose biosynthetic process
pentose-phosphate shunt
pentose-phosphate shunt, oxidative branch
small molecule metabolic process - Gene Ontology Molecular Function:
- phosphogluconate dehydrogenase (decarboxylating) activity
- Gene Ontology Cellular Component:
- cytosol
extracellular exosome
nucleus - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Gluconate utilization
NADP
Oxidoreductase
Pentose shunt
Phosphoprotein
Polymorphism
Reference proteome