Names & Taxonomy
- Uniprot ID:
- P42285
- Entry Name:
- SK2L2_HUMAN
- Status:
- reviewed
- Protein Names:
- Superkiller viralicidic activity 2-like 2 (EC 3.6.4.13) (ATP-dependent RNA helicase DOB1) (ATP-dependent RNA helicase SKIV2L2) (TRAMP-like complex helicase)
- Gene Names:
- SKIV2L2 DOB1 KIAA0052 Mtr4
- Gene Names Primary:
- SKIV2L2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1042
- Sequence:
- MADAFGDELFSVFEGDSTTAAGTKKDKEKDKGKWKGPPGSADKAGKRFDGKLQSESTNNGKNKRDVDFEGTDEPIFGKKPRIEESITEDLSLADLMPRVKVQSVETVEGCTHEVALPAEEDYLPLKPRVGKAAKEYPFILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIFTSPIKALSNQKYREMYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIPNARQFAEWICHLHKQPCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNTAMQVLRDAGDLAKGDQKGRKGGTKGPSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQMTKLDFNTDEEKKMVEEVFSNAIDCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNARKFDGKDFRWISSGEYIQMSGRAGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADPLNSAFHLTYNMVLNLLRVEEINPEYMLEKSFYQFQHYRAIPGVVEKVKNSEEQYNKIVIPNEESVVIYYKIRQQLAKLGKEIEEYIHKPKYCLPFLQPGRLVKVKNEGDDFGWGVVVNFSKKSNVKPNSGELDPLYVVEVLLRCSKESLKNSATEAAKPAKPDEKGEMQVVPVLVHLLSAISSVRLYIPKDLRPVDNRQSVLKSIQEVQKRFPDGIPLLDPIDDMGIQDQGLKKVIQKVEAFEHRMYSHPLHNDPNLETVYTLCEKKAQIAIDIKSAKRELKKARTVLQMDELKCRKRVLRRLGFATSSDVIEMKGRVACEISSADELLLTEMMFNGLFNDLSAEQATALLSCFVFQENSSEMPKLTEQLAGPLRQMQECAKRIAKVSAEAKLEIDEETYLSSFKPHLMDVVYTWATGATFAHICKMTDVFEGSIIRCMRRLEELLRQMCQAAKAIGNTELENKFAEGITKIKRDIVFAASLYL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus, nucleoplasm. Nucleus, nucleolus. Nucleus
Function
- Function:
- May be involved in pre-mRNA splicing. Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA.
- Catalytic Activity:
- ATP + H(2)O = ADP + phosphate.
- Gene Ontology Go:
- catalytic step 2 spliceosome
nucleolus
nucleoplasm
nucleus
ATP binding
poly(A) RNA binding
RNA helicase activity
maturation of 5.8S rRNA
mRNA splicing, via spliceosome
RNA catabolic process - Gene Ontology Biological Process:
- maturation of 5.8S rRNA
mRNA splicing, via spliceosome
RNA catabolic process - Gene Ontology Molecular Function:
- ATP binding
poly(A) RNA binding
RNA helicase activity - Gene Ontology Cellular Component:
- catalytic step 2 spliceosome
nucleolus
nucleoplasm
nucleus - Keywords:
- ATP-binding
Acetylation
Complete proteome
Direct protein sequencing
Helicase
Hydrolase
Isopeptide bond
Nucleotide-binding
Nucleus
Polymorphism
Reference proteome
Spliceosome
Ubl conjugation
mRNA processing
mRNA splicing
rRNA processing - Interacts With:
- Q99547