Names & Taxonomy
- Uniprot ID:
- P40261
- Entry Name:
- NNMT_HUMAN
- Status:
- reviewed
- Protein Names:
- Nicotinamide N-methyltransferase (EC 2.1.1.1)
- Gene Names:
- NNMT
- Gene Names Primary:
- NNMT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 264
- Sequence:
- MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQSYSSTMANNEGLFSLVARKLSRPL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.
- Catalytic Activity:
- S-adenosyl-L-methionine + nicotinamide = S-adenosyl-L-homocysteine + 1-methylnicotinamide.
- Cross Reference Drug Bank:
- DB00627
- Gene Ontology Go:
- cytosol
nicotinamide N-methyltransferase activity
cellular nitrogen compound metabolic process
methylation
organ regeneration
response to drug
response to organonitrogen compound
selenium compound metabolic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
methylation
organ regeneration
response to drug
response to organonitrogen compound
selenium compound metabolic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- nicotinamide N-methyltransferase activity
- Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Methyltransferase
Reference proteome
S-adenosyl-L-methionine
Transferase