Names & Taxonomy
- Uniprot ID:
- P28223
- Entry Name:
- 5HT2A_HUMAN
- Status:
- reviewed
- Protein Names:
- 5-hydroxytryptamine receptor 2A (5-HT-2) (5-HT-2A) (Serotonin receptor 2A)
- Gene Names:
- HTR2A HTR2
- Gene Names Primary:
- HTR2A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 471
- Sequence:
- MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein. Cell projection, dendrite
Function
- Function:
- G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
- Cross Reference Drug Bank:
- DB01614 DB06288 DB00321 DB00543 DB00714 DB01238 DB06216 DB09128 DB01200 DB09016 DB00248 DB06016 DB00477 DB01239 DB08810 DB00604 DB01242 DB00363 DB00924 DB00434 DB01151 DB00843 DB01142 DB00751 DB01049 DB00696 DB04908 DB00875 DB04842 DB00502 DB04946 DB00458 DB01221 DB00589 DB00408 DB08815 DB00934 DB00933 DB01403 DB00247 DB06148 DB00805 DB00370 DB01618 DB01149 DB00540 DB00334 DB01267 DB00715 DB01186 DB01621 DB00413 DB00420 DB01069 DB00777 DB01224 DB00409 DB00734 DB00268 DB06144 DB01622 DB00679 DB01623 DB00656 DB00726 DB01392 DB00246 DB01624
- Gene Ontology Go:
- axon
caveola
cell body fiber
cytoplasmic, membrane-bounded vesicle
cytosol
dendritic shaft
integral component of plasma membrane
neuronal cell body
plasma membrane
1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding
drug binding
G-protein coupled serotonin receptor activity
serotonin binding
virus receptor activity
activation of phospholipase C activity
aging
artery smooth muscle contraction
behavioral response to cocaine
cell death
cellular calcium ion homeostasis
detection of mechanical stimulus involved in sensory perception of pain
detection of temperature stimulus involved in sensory perception of pain
memory
negative regulation of potassium ion transport
negative regulation of synaptic transmission, glutamatergic
phosphatidylinositol 3-kinase signaling
phospholipase C-activating serotonin receptor signaling pathway
positive regulation of cell proliferation
positive regulation of ERK1 and ERK2 cascade
positive regulation of fat cell differentiation
positive regulation of glycolytic process
positive regulation of MAP kinase activity
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of phosphatidylinositol biosynthetic process
positive regulation of vasoconstriction
protein localization to cytoskeleton
regulation of behavior
regulation of dopamine secretion
regulation of hormone secretion
release of sequestered calcium ion into cytosol
response to drug
serotonin receptor signaling pathway
sleep
synaptic transmission
temperature homeostasis
urinary bladder smooth muscle contraction - Gene Ontology Biological Process:
- activation of phospholipase C activity
aging
artery smooth muscle contraction
behavioral response to cocaine
cell death
cellular calcium ion homeostasis
detection of mechanical stimulus involved in sensory perception of pain
detection of temperature stimulus involved in sensory perception of pain
memory
negative regulation of potassium ion transport
negative regulation of synaptic transmission, glutamatergic
phosphatidylinositol 3-kinase signaling
phospholipase C-activating serotonin receptor signaling pathway
positive regulation of cell proliferation
positive regulation of ERK1 and ERK2 cascade
positive regulation of fat cell differentiation
positive regulation of glycolytic process
positive regulation of MAP kinase activity
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of phosphatidylinositol biosynthetic process
positive regulation of vasoconstriction
protein localization to cytoskeleton
regulation of behavior
regulation of dopamine secretion
regulation of hormone secretion
release of sequestered calcium ion into cytosol
response to drug
serotonin receptor signaling pathway
sleep
synaptic transmission
temperature homeostasis
urinary bladder smooth muscle contraction - Gene Ontology Molecular Function:
- 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding
drug binding
G-protein coupled serotonin receptor activity
serotonin binding
virus receptor activity - Gene Ontology Cellular Component:
- axon
caveola
cell body fiber
cytoplasmic, membrane-bounded vesicle
cytosol
dendritic shaft
integral component of plasma membrane
neuronal cell body
plasma membrane - Keywords:
- Alternative splicing
Behavior
Cell membrane
Cell projection
Complete proteome
Cytoplasmic vesicle
Disulfide bond
G-protein coupled receptor
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix