Names & Taxonomy
- Uniprot ID:
- P23946
- Entry Name:
- CMA1_HUMAN
- Status:
- reviewed
- Protein Names:
- Chymase (EC 3.4.21.39) (Alpha-chymase) (Mast cell protease I)
- Gene Names:
- CMA1 CYH CYM
- Gene Names Primary:
- CMA1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 247
- Sequence:
- MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted. Cytoplasmic granule. Note=Mast cell granules.
Function
- Function:
- Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
- Catalytic Activity:
- Preferential cleavage: Phe-|-Xaa > Tyr-|-Xaa > Trp-|-Xaa > Leu-|-Xaa.
- Active Site:
- ACT_SITE 66 66 Charge relay system.; ACT_SITE 110 110 Charge relay system.; ACT_SITE 203 203 Charge relay system.
- Gene Ontology Go:
- cytoplasm
extracellular region
intracellular membrane-bounded organelle
peptide binding
serine-type endopeptidase activity
serine-type peptidase activity
angiotensin maturation
cellular protein metabolic process
cellular response to glucose stimulus
extracellular matrix disassembly
extracellular matrix organization
immune response
interleukin-1 beta biosynthetic process
midbrain development
positive regulation of angiogenesis
protein processing
regulation of inflammatory response - Gene Ontology Biological Process:
- angiotensin maturation
cellular protein metabolic process
cellular response to glucose stimulus
extracellular matrix disassembly
extracellular matrix organization
immune response
interleukin-1 beta biosynthetic process
midbrain development
positive regulation of angiogenesis
protein processing
regulation of inflammatory response - Gene Ontology Molecular Function:
- peptide binding
serine-type endopeptidase activity
serine-type peptidase activity - Gene Ontology Cellular Component:
- cytoplasm
extracellular region
intracellular membrane-bounded organelle - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Hydrolase
Polymorphism
Protease
Reference proteome
Secreted
Serine protease
Signal
Zymogen