Names & Taxonomy
- Uniprot ID:
- P20333
- Entry Name:
- TNR1B_HUMAN
- Status:
- reviewed
- Protein Names:
- Tumor necrosis factor receptor superfamily member 1B (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (TNF-RII) (TNFR-II) (p75) (p80 TNF-alpha receptor) (CD antigen CD120b) (Etanercept) [Cleaved into: Tumor necrosis factor receptor superfamily member 1b, membrane form; Tumor necrosis factor-binding protein 2 (TBP-2) (TBPII)]
- Gene Names:
- TNFRSF1B TNFBR TNFR2
- Gene Names Primary:
- TNFRSF1B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 461
- Sequence:
- MAPVAVWAALAVGLELWAAAHALPAQVAFTPYAPEPGSTCRLREYYDQTAQMCCSKCSPGQHAKVFCTKTSDTVCDSCEDSTYTQLWNWVPECLSCGSRCSSDQVETQACTREQNRICTCRPGWYCALSKQEGCRLCAPLRKCRPGFGVARPGTETSDVVCKPCAPGTFSNTTSSTDICRPHQICNVVAIPGNASMDAVCTSTSPTRSMAPGAVHLPQPVSTRSQHTQPTPEPSTAPSTSFLLPMGPSPPAEGSTGDFALPVGLIVGVTALGLLIIGVVNCVIMTQVKKKPLCLQREAKVPHLPADKARGTQGPEQQHLLITAPSSSSSSLESSASALDRRAPTRNQPQAPGVEASGAGEARASTGSSDSSPGGHGTQVNVTCIVNVCSSSDHSSQCSSQASSTMGDTDSSPSESPKDEQVPFSKEECAFRSQLETPETLLGSTEEKPLPLGVPDAGMKPS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted.; Tumor necrosis factor-binding protein 2: Secreted.
Function
- Function:
- Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
- Cross Reference Drug Bank:
- DB00005
- Gene Ontology Go:
- extracellular region
integral component of plasma membrane
membrane raft
neuronal cell body
nucleus
perinuclear region of cytoplasm
plasma membrane
varicosity
tumor necrosis factor-activated receptor activity
ubiquitin protein ligase binding
aging
apoptotic signaling pathway
cellular response to growth factor stimulus
cellular response to lipopolysaccharide
extrinsic apoptotic signaling pathway
immune response
inflammatory response
intrinsic apoptotic signaling pathway in response to DNA damage
multicellular organism development
negative regulation of inflammatory response
positive regulation of MAPK cascade
positive regulation of membrane protein ectodomain proteolysis
regulation of apoptotic process
regulation of cell proliferation
RNA destabilization
tumor necrosis factor-mediated signaling pathway - Gene Ontology Biological Process:
- aging
apoptotic signaling pathway
cellular response to growth factor stimulus
cellular response to lipopolysaccharide
extrinsic apoptotic signaling pathway
immune response
inflammatory response
intrinsic apoptotic signaling pathway in response to DNA damage
multicellular organism development
negative regulation of inflammatory response
positive regulation of MAPK cascade
positive regulation of membrane protein ectodomain proteolysis
regulation of apoptotic process
regulation of cell proliferation
RNA destabilization
tumor necrosis factor-mediated signaling pathway - Gene Ontology Molecular Function:
- tumor necrosis factor-activated receptor activity
ubiquitin protein ligase binding - Gene Ontology Cellular Component:
- extracellular region
integral component of plasma membrane
membrane raft
neuronal cell body
nucleus
perinuclear region of cytoplasm
plasma membrane
varicosity - Keywords:
- 3D-structure
Alternative splicing
Apoptosis
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Membrane
Pharmaceutical
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Secreted
Signal
Transmembrane
Transmembrane helix - Interacts With:
- P28799; P01375; Q12933