Names & Taxonomy
- Uniprot ID:
- P13726
- Entry Name:
- TF_HUMAN
- Status:
- reviewed
- Protein Names:
- Tissue factor (TF) (Coagulation factor III) (Thromboplastin) (CD antigen CD142)
- Gene Names:
- F3
- Gene Names Primary:
- F3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 295
- Sequence:
- METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPKPVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGSAGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFGKDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVECMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Membrane
Function
- Function:
- Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
- Cross Reference Drug Bank:
- DB00036
- Gene Ontology Go:
- cell surface
cytoplasm
extracellular exosome
extracellular matrix
extracellular space
integral component of membrane
intrinsic component of external side of plasma membrane
plasma membrane
cytokine receptor activity
phospholipid binding
protease binding
activation of blood coagulation via clotting cascade
activation of cysteine-type endopeptidase activity involved in apoptotic process
activation of plasma proteins involved in acute inflammatory response
aging
blood coagulation
blood coagulation, extrinsic pathway
cellular response to hydrogen peroxide
cytokine-mediated signaling pathway
positive regulation of angiogenesis
positive regulation of cell migration
positive regulation of endothelial cell proliferation
positive regulation of platelet-derived growth factor receptor signaling pathway
positive regulation of positive chemotaxis
positive regulation of protein kinase B signaling
positive regulation of smooth muscle cell migration
response to estradiol
response to fluid shear stress
response to lipopolysaccharide
response to low-density lipoprotein particle
response to mechanical stimulus
response to temperature stimulus - Gene Ontology Biological Process:
- activation of blood coagulation via clotting cascade
activation of cysteine-type endopeptidase activity involved in apoptotic process
activation of plasma proteins involved in acute inflammatory response
aging
blood coagulation
blood coagulation, extrinsic pathway
cellular response to hydrogen peroxide
cytokine-mediated signaling pathway
positive regulation of angiogenesis
positive regulation of cell migration
positive regulation of endothelial cell proliferation
positive regulation of platelet-derived growth factor receptor signaling pathway
positive regulation of positive chemotaxis
positive regulation of protein kinase B signaling
positive regulation of smooth muscle cell migration
response to estradiol
response to fluid shear stress
response to lipopolysaccharide
response to low-density lipoprotein particle
response to mechanical stimulus
response to temperature stimulus - Gene Ontology Molecular Function:
- cytokine receptor activity
phospholipid binding
protease binding - Gene Ontology Cellular Component:
- cell surface
cytoplasm
extracellular exosome
extracellular matrix
extracellular space
integral component of membrane
intrinsic component of external side of plasma membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Blood coagulation
Complete proteome
Disulfide bond
Glycoprotein
Hemostasis
Lipoprotein
Membrane
Palmitate
Polymorphism
Reference proteome
Secreted
Signal
Transmembrane
Transmembrane helix - Interacts With:
- P08709