Names & Taxonomy
- Uniprot ID:
- P09012
- Entry Name:
- SNRPA_HUMAN
- Status:
- reviewed
- Protein Names:
- U1 small nuclear ribonucleoprotein A (U1 snRNP A) (U1-A) (U1A)
- Gene Names:
- SNRPA
- Gene Names Primary:
- SNRPA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 282
- Sequence:
- MAVPETRPNHTIYINNLNEKIKKDELKKSLYAIFSQFGQILDILVSRSLKMRGQAFVIFKEVSSATNALRSMQGFPFYDKPMRIQYAKTDSDIIAKMKGTFVERDRKREKRKPKSQETPATKKAVQGGGATPVVGAVQGPVPGMPPMTQAPRIMHHMPGQPPYMPPPGMIPPPGLAPGQIPPGAMPPQQLMPGQMPPAQPLSENPPNHILFLTNLPEETNELMLSMLFNQFPGFKEVRLVPGRHDIAFVEFDNEVQAGAARDALQGFKITQNNAMKISFAKK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus.
Function
- Function:
- Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs.
- Gene Ontology Go:
- cytoplasm
nucleolus
nucleoplasm
spliceosomal complex
U1 snRNP
nucleotide binding
poly(A) RNA binding
RNA binding
snRNA stem-loop binding
U1 snRNA binding
gene expression
mRNA splicing, via spliceosome
RNA splicing - Gene Ontology Biological Process:
- gene expression
mRNA splicing, via spliceosome
RNA splicing - Gene Ontology Molecular Function:
- nucleotide binding
poly(A) RNA binding
RNA binding
snRNA stem-loop binding
U1 snRNA binding - Gene Ontology Cellular Component:
- cytoplasm
nucleolus
nucleoplasm
spliceosomal complex
U1 snRNP - Keywords:
- 3D-structure
Acetylation
Complete proteome
Direct protein sequencing
Nucleus
Phosphoprotein
RNA-binding
Reference proteome
Repeat
Ribonucleoprotein
Spliceosome
mRNA processing
mRNA splicing - Interacts With:
- Q14011; Q16206-2; Q06547; Q6IBN1; Q96PV6; Q8N6R0; Q5JR59; Q9BU61; Q9BU61-2; Q15365; Q15366; P26599; Q96PU8; P98179; P38159; P23246; P09661; P14373; P26368