Names & Taxonomy
- Uniprot ID:
- P08173
- Entry Name:
- ACM4_HUMAN
- Status:
- reviewed
- Protein Names:
- Muscarinic acetylcholine receptor M4
- Gene Names:
- CHRM4
- Gene Names Primary:
- CHRM4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 479
- Sequence:
- MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Function
- Function:
- The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.
- Cross Reference Drug Bank:
- DB08897 DB00321 DB00543 DB01238 DB00572 DB00835 DB01239 DB00568 DB00363 DB00785 DB00496 DB01151 DB01142 DB06702 DB00725 DB00424 DB00458 DB01625 DB01221 DB00408 DB00934 DB01403 DB00340 DB00622 DB00540 DB00334 DB00715 DB00454 DB00387 DB00420 DB01069 DB00777 DB01224 DB00747 DB01591 DB01036 DB00376 DB00726 DB00809 DB09076 DB00246
- Gene Ontology Go:
- asymmetric synapse
axon terminus
cell junction
cytoplasm
integral component of plasma membrane
neuronal cell body
plasma membrane
postsynaptic density
postsynaptic membrane
sarcolemma
synapse
G-protein coupled acetylcholine receptor activity
guanyl-nucleotide exchange factor activity
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
cell proliferation
cell surface receptor signaling pathway
G-protein coupled acetylcholine receptor signaling pathway
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
regulation of locomotion
response to organic substance
signal transduction
synaptic transmission, cholinergic - Gene Ontology Biological Process:
- adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
cell proliferation
cell surface receptor signaling pathway
G-protein coupled acetylcholine receptor signaling pathway
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
regulation of locomotion
response to organic substance
signal transduction
synaptic transmission, cholinergic - Gene Ontology Molecular Function:
- G-protein coupled acetylcholine receptor activity
guanyl-nucleotide exchange factor activity - Gene Ontology Cellular Component:
- asymmetric synapse
axon terminus
cell junction
cytoplasm
integral component of plasma membrane
neuronal cell body
plasma membrane
postsynaptic density
postsynaptic membrane
sarcolemma
synapse - Keywords:
- 3D-structure
Cell junction
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Phosphoprotein
Postsynaptic cell membrane
Receptor
Reference proteome
Synapse
Transducer
Transmembrane
Transmembrane helix