Names & Taxonomy
- Uniprot ID:
- Q9Y5N1
- Entry Name:
- HRH3_HUMAN
- Status:
- reviewed
- Protein Names:
- Histamine H3 receptor (H3R) (HH3R) (G-protein coupled receptor 97)
- Gene Names:
- HRH3 GPCR97
- Gene Names Primary:
- HRH3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 445
- Sequence:
- MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.
- Cross Reference Drug Bank:
- DB06698 DB00667 DB00370
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
presynapse
synapse
G-protein coupled acetylcholine receptor activity
histamine receptor activity
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
cognition
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
negative regulation of glutamate secretion
negative regulation of serotonin secretion
neurotransmitter secretion
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
regulation of norepinephrine secretion
synaptic transmission, cholinergic - Gene Ontology Biological Process:
- adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
cognition
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
negative regulation of glutamate secretion
negative regulation of serotonin secretion
neurotransmitter secretion
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
regulation of norepinephrine secretion
synaptic transmission, cholinergic - Gene Ontology Molecular Function:
- G-protein coupled acetylcholine receptor activity
histamine receptor activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane
presynapse
synapse - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
G-protein coupled receptor
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix