Names & Taxonomy
- Uniprot ID:
- Q9UQQ2
- Entry Name:
- SH2B3_HUMAN
- Status:
- reviewed
- Protein Names:
- SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk)
- Gene Names:
- SH2B3 LNK
- Gene Names Primary:
- SH2B3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 575
- Sequence:
- MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRAELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARSSEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAKKFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELFDPPKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMAELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFSLPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQHLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL
- Proteomes:
- UP000005640
Function
- Function:
- Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.
- Cross Reference Drug Bank:
- DB06589
- Gene Ontology Go:
- cytosol
signal transducer activity
signaling adaptor activity
blood coagulation
cell differentiation
embryonic hemopoiesis
intracellular signal transduction - Gene Ontology Biological Process:
- blood coagulation
cell differentiation
embryonic hemopoiesis
intracellular signal transduction - Gene Ontology Molecular Function:
- signaling adaptor activity
signal transducer activity - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- Complete proteome
Diabetes mellitus
Phosphoprotein
Polymorphism
Reference proteome
SH2 domain - Interacts With:
- P00533; P21860; P10721; P08581