Names & Taxonomy
- Uniprot ID:
- Q9UBN7
- Entry Name:
- HDAC6_HUMAN
- Status:
- reviewed
- Protein Names:
- Histone deacetylase 6 (HD6) (EC 3.5.1.98)
- Gene Names:
- HDAC6 KIAA0901 JM21
- Gene Names Orf:
- JM21
- Gene Names Primary:
- HDAC6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1215
- Sequence:
- MTSTGQDSTTTRQRRSRQNPQSPPQDSSVTSKRNIKKGAVPRSIPNLAEVKKKGKMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYDSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLESPGAPCRSAQASVSCALEALEPFWEVLVRSTETVERDNMEEDNVEESEEEGPWEPPVLPILTWPVLQSRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHRRYWRSLRVMKVEDREGPSSSKLVTKKAPQPAKPRLAERMTTREKKVLEAGMGKVTSASFGEESTPGQTNSETAVVALTQDQPSEAATGGATLAQTISEAAIGGAMLGQTTSEEAVGGATPDQTTSEETVGGAILDQTTSEDAVGGATLGQTTSEEAVGGATLAQTTSEAAMEGATLDQTTSEEAPGGTELIQTPLASSTDHQTPPTSPVQGTTPQISPSTLIGSLRTLELGSESQGASESQAPGEENLLGEAAGGQDMADSMLMQGSRGLTDQAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQENWVCLSCYQVYCGRYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKNIAHQNKFGEDMPHPH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus. Cytoplasm. Perikaryon
Function
- Function:
- Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
- Catalytic Activity:
- Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; ; Note=Binds 3 Zn(2+) ions per subunit.;
- Active Site:
- ACT_SITE 216 216 1.; ACT_SITE 611 611 2.
- Cross Reference Drug Bank:
- DB06603 DB02546
- Gene Ontology Go:
- aggresome
axon
caveola
cell leading edge
cytoplasm
cytoplasmic microtubule
cytosol
dendrite
histone deacetylase complex
inclusion body
microtubule
microtubule associated complex
multivesicular body
nucleus
perikaryon
perinuclear region of cytoplasm
alpha-tubulin binding
beta-catenin binding
core promoter binding
dynein complex binding
enzyme binding
histone deacetylase activity
histone deacetylase binding
Hsp90 protein binding
microtubule binding
misfolded protein binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
polyubiquitin binding
tau protein binding
tubulin deacetylase activity
ubiquitin protein ligase binding
zinc ion binding
aggresome assembly
cellular response to heat
cellular response to hydrogen peroxide
cellular response to misfolded protein
cellular response to topologically incorrect protein
histone deacetylation
Hsp90 deacetylation
intracellular protein transport
lysosome localization
macroautophagy
misfolded or incompletely synthesized protein catabolic process
mitochondrion localization
mitophagy in response to mitochondrial depolarization
negative regulation of hydrogen peroxide metabolic process
negative regulation of microtubule depolymerization
negative regulation of oxidoreductase activity
negative regulation of protein complex disassembly
negative regulation of proteolysis
negative regulation of transcription, DNA-templated
organelle organization
peptidyl-lysine deacetylation
polyubiquitinated misfolded protein transport
positive regulation of chaperone-mediated protein complex assembly
positive regulation of epithelial cell migration
positive regulation of hydrogen peroxide-mediated programmed cell death
positive regulation of receptor biosynthetic process
positive regulation of signal transduction
protein complex disassembly
protein deacetylation
protein polyubiquitination
regulation of androgen receptor signaling pathway
regulation of autophagy
regulation of establishment of protein localization
regulation of fat cell differentiation
regulation of gene expression, epigenetic
regulation of microtubule-based movement
regulation of mitophagy
regulation of protein stability
regulation of receptor activity
response to growth factor
response to misfolded protein
response to organic substance
response to toxic substance
transcription, DNA-templated
tubulin deacetylation
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway - Gene Ontology Biological Process:
- aggresome assembly
cellular response to heat
cellular response to hydrogen peroxide
cellular response to misfolded protein
cellular response to topologically incorrect protein
histone deacetylation
Hsp90 deacetylation
intracellular protein transport
lysosome localization
macroautophagy
misfolded or incompletely synthesized protein catabolic process
mitochondrion localization
mitophagy in response to mitochondrial depolarization
negative regulation of hydrogen peroxide metabolic process
negative regulation of microtubule depolymerization
negative regulation of oxidoreductase activity
negative regulation of protein complex disassembly
negative regulation of proteolysis
negative regulation of transcription, DNA-templated
organelle organization
peptidyl-lysine deacetylation
polyubiquitinated misfolded protein transport
positive regulation of chaperone-mediated protein complex assembly
positive regulation of epithelial cell migration
positive regulation of hydrogen peroxide-mediated programmed cell death
positive regulation of receptor biosynthetic process
positive regulation of signal transduction
protein complex disassembly
protein deacetylation
protein polyubiquitination
regulation of androgen receptor signaling pathway
regulation of autophagy
regulation of establishment of protein localization
regulation of fat cell differentiation
regulation of gene expression, epigenetic
regulation of microtubule-based movement
regulation of mitophagy
regulation of protein stability
regulation of receptor activity
response to growth factor
response to misfolded protein
response to organic substance
response to toxic substance
transcription, DNA-templated
tubulin deacetylation
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway - Gene Ontology Molecular Function:
- alpha-tubulin binding
beta-catenin binding
core promoter binding
dynein complex binding
enzyme binding
histone deacetylase activity
histone deacetylase binding
Hsp90 protein binding
microtubule binding
misfolded protein binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
polyubiquitin binding
tau protein binding
tubulin deacetylase activity
ubiquitin protein ligase binding
zinc ion binding - Gene Ontology Cellular Component:
- aggresome
axon
caveola
cell leading edge
cytoplasm
cytoplasmic microtubule
cytosol
dendrite
histone deacetylase complex
inclusion body
microtubule
microtubule associated complex
multivesicular body
nucleus
perikaryon
perinuclear region of cytoplasm - Keywords:
- 3D-structure
Actin-binding
Alternative splicing
Autophagy
Cell projection
Chromatin regulator
Complete proteome
Cytoplasm
Hydrolase
Metal-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Repressor
Transcription
Transcription regulation
Ubl conjugation
Zinc
Zinc-finger - Interacts With:
- P21146; Q9NQ11; Q9HCU9; Q62623; Q14247; Q60598; Q9NQC7; P00533; P17252; P03409