Names & Taxonomy
- Uniprot ID:
- Q9HBL8
- Entry Name:
- NMRL1_HUMAN
- Status:
- reviewed
- Protein Names:
- NmrA-like family domain-containing protein 1
- Gene Names:
- NMRAL1 HSCARG
- Gene Names Primary:
- NMRAL1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 299
- Sequence:
- MVDKKLVVVFGGTGAQGGSVARTLLEDGTFKVRVVTRNPRKKAAKELRLQGAEVVQGDQDDQVIMELALNGAYATFIVTNYWESCSQEQEVKQGKLLADLARRLGLHYVVYSGLENIKKLTAGRLAAAHFDGKGEVEEYFRDIGVPMTSVRLPCYFENLLSHFLPQKAPDGKSYLLSLPTGDVPMDGMSVSDLGPVVLSLLKMPEKYVGQNIGLSTCRHTAEEYAALLTKHTRKVVHDAKMTPEDYEKLGFPGARDLANMFRFYALRPDRDIELTLRLNPKALTLDQWLEQHKGDFNLL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Under normal redox growth conditions localizes in the cytoplasm and perinuclear region. Nuclear localization is promoted by increased intracellular nitric oxide and reduced NADPH/NADP(+) ratios.
Function
- Function:
- Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer.
- Gene Ontology Go:
- cytoplasm
nucleus
perinuclear region of cytoplasm - Gene Ontology Cellular Component:
- cytoplasm
nucleus
perinuclear region of cytoplasm - Keywords:
- 3D-structure
Complete proteome
Cytoplasm
NADP
Nucleus
Polymorphism
Reference proteome