Names & Taxonomy
- Uniprot ID:
- Q9GZT4
- Entry Name:
- SRR_HUMAN
- Status:
- reviewed
- Protein Names:
- Serine racemase (EC 5.1.1.18) (D-serine ammonia-lyase) (D-serine dehydratase) (EC 4.3.1.18) (L-serine ammonia-lyase) (L-serine dehydratase) (EC 4.3.1.17)
- Gene Names:
- SRR
- Gene Names Primary:
- SRR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 340
- Sequence:
- MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNICIVLSGGNVDLTSSITWVKQAERPASYQSVSV
- Proteomes:
- UP000005640
Function
- Function:
- Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.
- Catalytic Activity:
- L-serine = D-serine.
- Cofactor:
- COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=6.5 mM for L-serine
- Enzyme Regulation:
- ENZYME REGULATION: Allosterically activated by magnesium, and possibly also other divalent metal cations. Allosterically activated by ATP, ADP or GTP. Competitively inhibited by malonate.
- Active Site:
- ACT_SITE 56 56 Proton acceptor.
- Cross Reference Drug Bank:
- DB00133
- Gene Ontology Go:
- apical part of cell
cytoplasm
neuronal cell body
plasma membrane
ATP binding
calcium ion binding
D-serine ammonia-lyase activity
glycine binding
L-serine ammonia-lyase activity
magnesium ion binding
PDZ domain binding
protein homodimerization activity
pyridoxal phosphate binding
serine racemase activity
threonine racemase activity
aging
brain development
D-serine biosynthetic process
D-serine metabolic process
L-serine metabolic process
protein homotetramerization
pyruvate biosynthetic process
response to drug
response to lipopolysaccharide
response to morphine
serine family amino acid metabolic process - Gene Ontology Biological Process:
- aging
brain development
D-serine biosynthetic process
D-serine metabolic process
L-serine metabolic process
protein homotetramerization
pyruvate biosynthetic process
response to drug
response to lipopolysaccharide
response to morphine
serine family amino acid metabolic process - Gene Ontology Molecular Function:
- ATP binding
calcium ion binding
D-serine ammonia-lyase activity
glycine binding
L-serine ammonia-lyase activity
magnesium ion binding
PDZ domain binding
protein homodimerization activity
pyridoxal phosphate binding
serine racemase activity
threonine racemase activity - Gene Ontology Cellular Component:
- apical part of cell
cytoplasm
neuronal cell body
plasma membrane - Keywords:
- 3D-structure
ATP-binding
Allosteric enzyme
Complete proteome
Direct protein sequencing
Isomerase
Lyase
Magnesium
Metal-binding
Nucleotide-binding
Pyridoxal phosphate
Reference proteome
S-nitrosylation