Names & Taxonomy
- Uniprot ID:
- Q9BQS7
- Entry Name:
- HEPH_HUMAN
- Status:
- reviewed
- Protein Names:
- Hephaestin (EC 1.-.-.-)
- Gene Names:
- HEPH KIAA0698 UNQ2562/PRO6242
- Gene Names Orf:
- UNQ2562/PRO6242
- Gene Names Primary:
- HEPH
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1158
- Sequence:
- MESGHLLWALLFMQSLWPQLTDGATRVYYLGIRDVQWNYAPKGRNVITNQPLDSDIVASSFLKSDKNRIGGTYKKTIYKEYKDDSYTDEVAQPAWLGFLGPVLQAEVGDVILIHLKNFATRPYTIHPHGVFYEKDSEGSLYPDGSSGPLKADDSVPPGGSHIYNWTIPEGHAPTDADPACLTWIYHSHVDAPRDIATGLIGPLITCKRGALDGNSPPQRQDVDHDFFLLFSVVDENLSWHLNENIATYCSDPASVDKEDETFQESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQRYQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLESTTVWPLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDETFLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENYRADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSPLTVITKETEKAVPPRDIEEGNVKMLGMQIPIKNVEMLASVLVAISVTLLLVVLALGGVVWYQHRQRKLRRNRRSILDDSFKLLSFKQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1.
- Cofactor:
- COFACTOR: Name=Cu cation; Xref=ChEBI:CHEBI:23378;
- Gene Ontology Go:
- basolateral plasma membrane
integral component of membrane
intracellular
perinuclear region of cytoplasm
plasma membrane
copper ion binding
ferrous iron binding
ferroxidase activity
cellular iron ion homeostasis
copper ion transport
iron ion transport
transmembrane transport - Gene Ontology Biological Process:
- cellular iron ion homeostasis
copper ion transport
iron ion transport
transmembrane transport - Gene Ontology Molecular Function:
- copper ion binding
ferrous iron binding
ferroxidase activity - Gene Ontology Cellular Component:
- basolateral plasma membrane
integral component of membrane
intracellular
perinuclear region of cytoplasm
plasma membrane - Keywords:
- Alternative splicing
Complete proteome
Copper
Copper transport
Disulfide bond
Glycoprotein
Ion transport
Iron
Iron transport
Membrane
Metal-binding
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix
Transport