Names & Taxonomy
- Uniprot ID:
- Q96HD9
- Entry Name:
- ACY3_HUMAN
- Status:
- reviewed
- Protein Names:
- N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) (EC 3.5.1.114) (Acylase III) (Aminoacylase-3) (ACY-3) (Aspartoacylase-2) (Hepatitis C virus core-binding protein 1) (HCBP1) (HCV core-binding protein 1)
- Gene Names:
- ACY3 ASPA2
- Gene Names Primary:
- ACY3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 319
- Sequence:
- MCSLPVPREPLRRVAVTGGTHGNEMSGVYLARHWLHAPAELQRASFSAVPVLANPAATSGCRRYVDHDLNRTFTSSFLNSRPTPDDPYEVTRARELNQLLGPKASGQAFDFVLDLHNTTANMGTCLIAKSSHEVFAMHLCRHLQLQYPELSCQVFLYQRSGEESYNLDSVAKNGLGLELGPQPQGVLRADIFSRMRTLVATVLDFIELFNQGTAFPAFEMEAYRPVGVVDFPRTEAGHLAGTVHPQLQDRDFQPLQPGAPIFQMFSGEDLLYEGESTVYPVFINEAAYYEKGVAFVQTEKFTFTVPAMPALTPAPSPAS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Apical cell membrane
Function
- Function:
- Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acids (By similarity).
- Catalytic Activity:
- An N-acyl-aromatic-L-amino acid + H(2)O = an aromatic-L-amino acid + a carboxylate.; An N-acetyl-L-cysteine-S-conjugate + H(2)O = an L-cysteine-S-conjugate + acetate.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Cross Reference Drug Bank:
- DB00128
- Gene Ontology Go:
- apical plasma membrane
cytosol
extracellular exosome
aminoacylase activity
hydrolase activity, acting on ester bonds
metal ion binding
small molecule metabolic process
viral process
xenobiotic metabolic process - Gene Ontology Biological Process:
- small molecule metabolic process
viral process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- aminoacylase activity
hydrolase activity, acting on ester bonds
metal ion binding - Gene Ontology Cellular Component:
- apical plasma membrane
cytosol
extracellular exosome - Keywords:
- Cell membrane
Complete proteome
Cytoplasm
Host-virus interaction
Hydrolase
Membrane
Metal-binding
Polymorphism
Reference proteome
Zinc - Interacts With:
- Q9H7C9; P45381; Q9H8Y8; Q8TBB1; Q7Z3S9; O75928; Q9H8W4; O15305