Names & Taxonomy
- Uniprot ID:
- Q8N543
- Entry Name:
- OGFD1_HUMAN
- Status:
- reviewed
- Protein Names:
- Prolyl 3-hydroxylase OGFOD1 (EC 1.14.11.-) (2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1) (Termination and polyadenylation 1 homolog)
- Gene Names:
- OGFOD1 KIAA1612 TPA1
- Gene Names Primary:
- OGFOD1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 542
- Sequence:
- MNGKRPAEPGPARVGKKGKKEVMAEFSDAVTEETLKKQVAEAWSRRTPFSHEVIVMDMDPFLHCVIPNFIQSQDFLEGLQKELMNLDFHEKYNDLYKFQQSDDLKKRREPHISTLRKILFEDFRSWLSDISKIDLESTIDMSCAKYEFTDALLCHDDELEGRRIAFILYLVPPWDRSMGGTLDLYSIDEHFQPKQIVKSLIPSWNKLVFFEVSPVSFHQVSEVLSEEKSRLSISGWFHGPSLTRPPNYFEPPIPRSPHIPQDHEILYDWINPTYLDMDYQVQIQEEFEESSEILLKEFLKPEKFTKVCEALEHGHVEWSSRGPPNKRFYEKAEESKLPEILKECMKLFRSEALFLLLSNFTGLKLHFLAPSEEDEMNDKKEAETTDITEEGTSHSPPEPENNQMAISNNSQQSNEQTDPEPEENETKKESSVPMCQGELRHWKTGHYTLIHDHSKAEFALDLILYCGCEGWEPEYGGFTSYIAKGEDEELLTVNPESNSLALVYRDRETLKFVKHINHRSLEQKKTFPNRTGFWDFSFIYYE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Cytoplasm. Nucleus. Note=Mainly nuclear. A portion relocalizes to cytoplasmic stress granules upon stress.; Isoform 2: Cytoplasm.
Function
- Function:
- Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit RPS23, thereby regulating protein translation termination efficiency. Involved in stress granule formation.
- Catalytic Activity:
- Peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-3-hydroxy-L-proline + succinate + CO2.
- Cofactor:
- COFACTOR: Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
- Cross Reference Drug Bank:
- DB00126
- Gene Ontology Go:
- cytoplasm
cytoplasmic stress granule
nucleus
iron ion binding
L-ascorbic acid binding
peptidyl-proline 3-dioxygenase activity
peptidyl-proline dioxygenase activity
cell proliferation
peptidyl-proline hydroxylation
protein hydroxylation
regulation of translational termination
stress granule assembly - Gene Ontology Biological Process:
- cell proliferation
peptidyl-proline hydroxylation
protein hydroxylation
regulation of translational termination
stress granule assembly - Gene Ontology Molecular Function:
- iron ion binding
L-ascorbic acid binding
peptidyl-proline 3-dioxygenase activity
peptidyl-proline dioxygenase activity - Gene Ontology Cellular Component:
- cytoplasm
cytoplasmic stress granule
nucleus - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Dioxygenase
Iron
Metal-binding
Nucleus
Oxidoreductase
Polymorphism
Reference proteome
Vitamin C