Names & Taxonomy
- Uniprot ID:
- Q8IUH5
- Entry Name:
- ZDH17_HUMAN
- Status:
- reviewed
- Protein Names:
- Palmitoyltransferase ZDHHC17 (EC 2.3.1.225) (Huntingtin yeast partner H) (Huntingtin-interacting protein 14) (HIP-14) (Huntingtin-interacting protein 3) (HIP-3) (Huntingtin-interacting protein H) (Putative MAPK-activating protein PM11) (Putative NF-kappa-B-activating protein 205) (Zinc finger DHHC domain-containing protein 17) (DHHC-17)
- Gene Names:
- ZDHHC17 HIP14 HIP3 HYPH KIAA0946 HSPC294
- Gene Names Orf:
- HSPC294
- Gene Names Primary:
- ZDHHC17
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 632
- Sequence:
- MQREEGFNTKMADGPDEYDTEAGCVPLLHPEEIKPQSHYNHGYGEPLGRKTHIDDYSTWDIVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLAKQRKNVWMINHLQEARQAKGYDNPSFLRKLKADKEFRQKVMLGTPFLVIWLVGFIADLNIDSWLIKGLMYGGVWATVQFLSKSFFDHSMHSALPLGIYLATKFWMYVTWFFWFWNDLNFLFIHLPFLANSVALFYNFGKSWKSDPGIIKATEEQKKKTIVELAETGSLDLSIFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHRYFMGYLFFLLFMICWMIYGCISYWGLHCETTYTKDGFWTYITQIATCSPWMFWMFLNSVFHFMWVAVLLMCQMYQISCLGITTNERMNARRYKHFKVTTTSIESPFNHGCVRNIIDFFEFRCCGLFRPVIVDWTRQYTIEYDQISGSGYQLV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Golgi apparatus membrane
Function
- Function:
- Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD (PubMed:15603740, PubMed:15489887, PubMed:19139280). Palmitoylates MPP1 in erythrocytes (PubMed:22496366). May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane (PubMed:12393793). May play a role in Mg(2+) transport (PubMed:18794299).
- Catalytic Activity:
- Palmitoyl-CoA + -L-cysteine = -S-palmitoyl-L-cysteine + CoA.
- Active Site:
- ACT_SITE 467 467 S-palmitoyl cysteine intermediate.
- Gene Ontology Go:
- cytoplasm
Golgi apparatus
Golgi membrane
Golgi-associated vesicle membrane
integral component of membrane
intracellular membrane-bounded organelle
identical protein binding
magnesium ion transmembrane transporter activity
palmitoyltransferase activity
protein-cysteine S-palmitoyltransferase activity
signal transducer activity
zinc ion binding
lipoprotein transport
magnesium ion transmembrane transport
positive regulation of I-kappaB kinase/NF-kappaB signaling
protein palmitoylation
signal transduction - Gene Ontology Biological Process:
- lipoprotein transport
magnesium ion transmembrane transport
positive regulation of I-kappaB kinase/NF-kappaB signaling
protein palmitoylation
signal transduction - Gene Ontology Molecular Function:
- identical protein binding
magnesium ion transmembrane transporter activity
palmitoyltransferase activity
protein-cysteine S-palmitoyltransferase activity
signal transducer activity
zinc ion binding - Gene Ontology Cellular Component:
- cytoplasm
Golgi apparatus
Golgi-associated vesicle membrane
Golgi membrane
integral component of membrane
intracellular membrane-bounded organelle - Keywords:
- 3D-structure
ANK repeat
Acyltransferase
Alternative splicing
Complete proteome
Cytoplasmic vesicle
Golgi apparatus
Lipoprotein
Membrane
Metal-binding
Palmitate
Polymorphism
Reference proteome
Repeat
Transferase
Transmembrane
Transmembrane helix
Tumor suppressor
Zinc
Zinc-finger - Interacts With:
- Itself; Q7Z783; Q7Z5R6; Q9NP61; P15336; Q9UQB8-3; Q9UQB8-6; P17655; Q96GN5-2; P48730-2; P68104; P60228; Q9UI08-2; Q9UHY8; Q08379; Q9H4A5; P51674; P49840; P42858; Q8IY31-3; Q9NWB7; O60259; Q14847-2; Q96CV9-2; Q08499-8; O15530-4; P27986-2; Q9UF11-4; Q16537; Q96DA2; Q15047-2; Q8IVB4; O00161; P60880; Q7Z699; Q7Z698; O43597; Q9C004; Q8NFA0; Q9Y6W5