Names & Taxonomy
- Uniprot ID:
- Q86XF0
- Entry Name:
- DYRL1_HUMAN
- Status:
- reviewed
- Protein Names:
- Dihydrofolate reductase, mitochondrial (EC 1.5.1.3) (Dihydrofolate reductase-like protein 1)
- Gene Names:
- DHFRL1 DHFRP4
- Gene Names Primary:
- DHFRL1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 187
- Sequence:
- MFLLLNCIVAVSQNMGIGKNGDLPRPPLRNEFRYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINLVLSRELKEPPQGAHFLARSLDDALKLTERPELANKVDMIWIVGGSSVYKEAMNHLGHLKLFVTRIMQDFESDTFFSEIDLEKYKLLPEYPGVLSDVQEGKHIKYKFEVCEKDD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion
Function
- Function:
- Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR.
- Pathway:
- Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.
- Catalytic Activity:
- 5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=209 uM for dihydrofolate
- Gene Ontology Go:
- mitochondrial inner membrane
mitochondrial matrix
mitochondrion
dihydrofolate reductase activity
mRNA binding
NADP binding
glycine biosynthetic process
nucleotide biosynthetic process
one-carbon metabolic process
tetrahydrofolate biosynthetic process
tetrahydrofolate metabolic process
thymidine biosynthetic process - Gene Ontology Biological Process:
- glycine biosynthetic process
nucleotide biosynthetic process
one-carbon metabolic process
tetrahydrofolate biosynthetic process
tetrahydrofolate metabolic process
thymidine biosynthetic process - Gene Ontology Molecular Function:
- dihydrofolate reductase activity
mRNA binding
NADP binding - Gene Ontology Cellular Component:
- mitochondrial inner membrane
mitochondrial matrix
mitochondrion - Keywords:
- Complete proteome
Membrane
Mitochondrion
Mitochondrion inner membrane
NADP
One-carbon metabolism
Oxidoreductase
Polymorphism
Reference proteome