Names & Taxonomy
- Uniprot ID:
- Q16831
- Entry Name:
- UPP1_HUMAN
- Status:
- reviewed
- Protein Names:
- Uridine phosphorylase 1 (UPase 1) (UrdPase 1) (EC 2.4.2.3)
- Gene Names:
- UPP1 UP
- Gene Names Primary:
- UPP1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 310
- Sequence:
- MAATGANAEKAESHNDCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALFGDVKFVCVGGSPSRMKAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKVGPVLSVSHGMGIPSISIMLHELIKLLYYARCSNVTIIRIGTSGGIGLEPGTVVITEQAVDTCFKAEFEQIVLGKRVIRKTDLNKKLVQELLLCSAELSEFTTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLEAAYAAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRLEGDQISSPRNVLSEYQQRPQRLVSYFIKKKLSKA
- Proteomes:
- UP000005640
Function
- Function:
- Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate (PubMed:7488099). The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
- Pathway:
- Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1.
- Catalytic Activity:
- Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.
- Cross Reference Drug Bank:
- DB00544
- Gene Ontology Go:
- cytosol
uridine phosphorylase activity
cellular response to glucose starvation
nucleobase-containing compound metabolic process
nucleobase-containing small molecule metabolic process
nucleotide catabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside catabolic process
pyrimidine nucleoside salvage
small molecule metabolic process
UMP salvage
uridine catabolic process - Gene Ontology Biological Process:
- cellular response to glucose starvation
nucleobase-containing compound metabolic process
nucleobase-containing small molecule metabolic process
nucleotide catabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside catabolic process
pyrimidine nucleoside salvage
small molecule metabolic process
UMP salvage
uridine catabolic process - Gene Ontology Molecular Function:
- uridine phosphorylase activity
- Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Glycosyltransferase
Reference proteome
Transferase