Names & Taxonomy
- Uniprot ID:
- Q16720
- Entry Name:
- AT2B3_HUMAN
- Status:
- reviewed
- Protein Names:
- Plasma membrane calcium-transporting ATPase 3 (PMCA3) (EC 3.6.3.8) (Plasma membrane calcium ATPase isoform 3) (Plasma membrane calcium pump isoform 3)
- Gene Names:
- ATP2B3
- Gene Names Primary:
- ATP2B3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1220
- Sequence:
- MGDMANSSIEFHPKPQQQRDVPQAGGFGCTLAELRTLMELRGAEALQKIEEAYGDVSGLCRRLKTSPTEGLADNTNDLEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSLGLSFYAPPGEESEACGNVSGGAEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQANDLKIDESSLTGESDHVRKSADKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDKKGKQQDGAMESSQTKAKKQDGAVAMEMQPLKSAEGGEMEEREKKKANAPKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFVIETFVVEGRTWLAECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYLGDTHYKEIPAPSALTPKILDLLVHAISINSAYTTKILPPEKEGALPRQVGNKTECALLGFVLDLKRDFQPVREQIPEDKLYKVYTFNSVRKSMSTVIRMPDGGFRLFSKGASEILLKKCTNILNSNGELRGFRPRDRDDMVRKIIEPMACDGLRTICIAYRDFSAGQEPDWDNENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQPGEDFLCLEGKEFNRRIRNEKGEIEQERLDKVWPKLRVLARSSPTDKHTLVKGIIDSTTGEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRDKPLISRTMMKNILGHAVYQLAIIFTLLFVGELFFDIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFSNPIFCTIVLGTFGIQIVIVQFGGKPFSCSPLSTEQWLWCLFVGVGELVWGQVIATIPTSQLKCLKEAGHGPGKDEMTDEELAEGEEEIDHAERELRRGQILWFRGLNRIQTQIRVVKAFRSSLYEGLEKPESKTSIHNFMATPEFLINDYTHNIPLIDDTDVDENEERLRAPPPPSPNQNNNAIDSGIYLTTHVTKSATSSVFSSSPGSPLHSVETSL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.
- Catalytic Activity:
- ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2).
- Active Site:
- ACT_SITE 473 473 4-aspartylphosphate intermediate.
- Gene Ontology Go:
- extracellular vesicle
Golgi apparatus
integral component of plasma membrane
intracellular membrane-bounded organelle
plasma membrane
ATP binding
calcium-transporting ATPase activity
metal ion binding
PDZ domain binding
blood coagulation
cardiac conduction
cellular calcium ion homeostasis
ion transmembrane transport
regulation of cardiac conduction
transmembrane transport
transport - Gene Ontology Biological Process:
- blood coagulation
cardiac conduction
cellular calcium ion homeostasis
ion transmembrane transport
regulation of cardiac conduction
transmembrane transport
transport - Gene Ontology Molecular Function:
- ATP binding
calcium-transporting ATPase activity
metal ion binding
PDZ domain binding - Gene Ontology Cellular Component:
- extracellular vesicle
Golgi apparatus
integral component of plasma membrane
intracellular membrane-bounded organelle
plasma membrane - Keywords:
- ATP-binding
Alternative splicing
Calcium
Calcium transport
Calmodulin-binding
Cell membrane
Complete proteome
Disease mutation
Hydrolase
Ion transport
Magnesium
Membrane
Metal-binding
Neurodegeneration
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport