Names & Taxonomy
- Uniprot ID:
- Q16665
- Entry Name:
- HIF1A_HUMAN
- Status:
- reviewed
- Protein Names:
- Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)
- Gene Names:
- HIF1A BHLHE78 MOP1 PASD8
- Gene Names Primary:
- HIF1A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 826
- Sequence:
- MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKRKMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLACRLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.
- Cross Reference Drug Bank:
- DB01136
- Gene Ontology Go:
- axon
cytoplasm
cytosol
motile cilium
nuclear speck
nucleoplasm
nucleus
RNA polymerase II transcription factor complex
transcription factor complex
enzyme binding
histone acetyltransferase binding
Hsp90 protein binding
nuclear hormone receptor binding
protein heterodimerization activity
protein kinase binding
sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription factor activity, RNA polymerase II transcription factor binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, transcription factor binding
transcription factor binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
ubiquitin protein ligase binding
acute-phase response
angiogenesis
axon transport of mitochondrion
B-1 B cell homeostasis
cardiac ventricle morphogenesis
cartilage development
cellular iron ion homeostasis
cellular response to carbon monoxide
cellular response to cobalt ion
cellular response to cyanide
cellular response to drug
cellular response to electrical stimulus
cellular response to glucose stimulus
cellular response to hydrogen peroxide
cellular response to hypoxia
cellular response to insulin stimulus
cellular response to interleukin-1
cellular response to light stimulus
cellular response to lipopolysaccharide
cellular response to mechanical stimulus
cellular response to nitrite
cellular response to organic cyclic compound
cellular response to toxic substance
cerebral cortex development
collagen metabolic process
connective tissue replacement involved in inflammatory response wound healing
digestive tract morphogenesis
dopaminergic neuron differentiation
elastin metabolic process
embryonic hemopoiesis
embryonic placenta development
epithelial cell differentiation involved in mammary gland alveolus development
epithelial to mesenchymal transition
heart looping
hemoglobin biosynthetic process
hypoxia-inducible factor-1alpha signaling pathway
intestinal epithelial cell maturation
iris morphogenesis
lactate metabolic process
lactation
maternal process involved in female pregnancy
mRNA transcription from RNA polymerase II promoter
muscle cell cellular homeostasis
negative regulation of bone mineralization
negative regulation of growth
negative regulation of mesenchymal cell apoptotic process
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
negative regulation of reactive oxygen species metabolic process
negative regulation of thymocyte apoptotic process
negative regulation of TOR signaling
negative regulation of transcription from RNA polymerase II promoter
negative regulation of vasoconstriction
neural crest cell migration
neural fold elevation formation
Notch signaling pathway
outflow tract morphogenesis
oxygen homeostasis
positive regulation of angiogenesis
positive regulation of apoptotic process
positive regulation of cell size
positive regulation of chemokine production
positive regulation of chemokine-mediated signaling pathway
positive regulation of endothelial cell proliferation
positive regulation of epithelial cell migration
positive regulation of erythrocyte differentiation
positive regulation of gene expression
positive regulation of glycolytic process
positive regulation of hormone biosynthetic process
positive regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of mitophagy
positive regulation of neuroblast proliferation
positive regulation of nitric-oxide synthase activity
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of receptor biosynthetic process
positive regulation of smooth muscle cell proliferation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
positive regulation of transcription, DNA-templated
positive regulation of vascular endothelial growth factor production
positive regulation of vascular endothelial growth factor receptor signaling pathway
regulation of aerobic respiration
regulation of cellular response to hypoxia
regulation of gene expression
regulation of transcription from RNA polymerase II promoter in response to hypoxia
regulation of transcription from RNA polymerase II promoter in response to oxidative stress
regulation of transcription, DNA-templated
regulation of transforming growth factor beta2 production
response to alkaloid
response to anesthetic
response to auditory stimulus
response to estradiol
response to fungicide
response to glucocorticoid
response to hypoxia
response to muscle activity
response to purine-containing compound
response to salt stress
response to X-ray
retina vasculature development in camera-type eye
signal transduction
transcription from RNA polymerase II promoter
vascular endothelial growth factor production
visual learning - Gene Ontology Biological Process:
- acute-phase response
angiogenesis
axon transport of mitochondrion
B-1 B cell homeostasis
cardiac ventricle morphogenesis
cartilage development
cellular iron ion homeostasis
cellular response to carbon monoxide
cellular response to cobalt ion
cellular response to cyanide
cellular response to drug
cellular response to electrical stimulus
cellular response to glucose stimulus
cellular response to hydrogen peroxide
cellular response to hypoxia
cellular response to insulin stimulus
cellular response to interleukin-1
cellular response to light stimulus
cellular response to lipopolysaccharide
cellular response to mechanical stimulus
cellular response to nitrite
cellular response to organic cyclic compound
cellular response to toxic substance
cerebral cortex development
collagen metabolic process
connective tissue replacement involved in inflammatory response wound healing
digestive tract morphogenesis
dopaminergic neuron differentiation
elastin metabolic process
embryonic hemopoiesis
embryonic placenta development
epithelial cell differentiation involved in mammary gland alveolus development
epithelial to mesenchymal transition
heart looping
hemoglobin biosynthetic process
hypoxia-inducible factor-1alpha signaling pathway
intestinal epithelial cell maturation
iris morphogenesis
lactate metabolic process
lactation
maternal process involved in female pregnancy
mRNA transcription from RNA polymerase II promoter
muscle cell cellular homeostasis
negative regulation of bone mineralization
negative regulation of growth
negative regulation of mesenchymal cell apoptotic process
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
negative regulation of reactive oxygen species metabolic process
negative regulation of thymocyte apoptotic process
negative regulation of TOR signaling
negative regulation of transcription from RNA polymerase II promoter
negative regulation of vasoconstriction
neural crest cell migration
neural fold elevation formation
Notch signaling pathway
outflow tract morphogenesis
oxygen homeostasis
positive regulation of angiogenesis
positive regulation of apoptotic process
positive regulation of cell size
positive regulation of chemokine-mediated signaling pathway
positive regulation of chemokine production
positive regulation of endothelial cell proliferation
positive regulation of epithelial cell migration
positive regulation of erythrocyte differentiation
positive regulation of gene expression
positive regulation of glycolytic process
positive regulation of hormone biosynthetic process
positive regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of mitophagy
positive regulation of neuroblast proliferation
positive regulation of nitric-oxide synthase activity
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of receptor biosynthetic process
positive regulation of smooth muscle cell proliferation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
positive regulation of vascular endothelial growth factor production
positive regulation of vascular endothelial growth factor receptor signaling pathway
regulation of aerobic respiration
regulation of cellular response to hypoxia
regulation of gene expression
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter in response to hypoxia
regulation of transcription from RNA polymerase II promoter in response to oxidative stress
regulation of transforming growth factor beta2 production
response to alkaloid
response to anesthetic
response to auditory stimulus
response to estradiol
response to fungicide
response to glucocorticoid
response to hypoxia
response to muscle activity
response to purine-containing compound
response to salt stress
response to X-ray
retina vasculature development in camera-type eye
signal transduction
transcription from RNA polymerase II promoter
vascular endothelial growth factor production
visual learning - Gene Ontology Molecular Function:
- enzyme binding
histone acetyltransferase binding
Hsp90 protein binding
nuclear hormone receptor binding
protein heterodimerization activity
protein kinase binding
sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription factor activity, RNA polymerase II transcription factor binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, transcription factor binding
transcription factor binding
ubiquitin protein ligase binding - Gene Ontology Cellular Component:
- axon
cytoplasm
cytosol
motile cilium
nuclear speck
nucleoplasm
nucleus
RNA polymerase II transcription factor complex
transcription factor complex - Keywords:
- 3D-structure
Acetylation
Activator
Alternative splicing
Complete proteome
Cytoplasm
DNA-binding
Direct protein sequencing
Hydroxylation
Isopeptide bond
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repeat
S-nitrosylation
Transcription
Transcription regulation
Ubl conjugation - Interacts With:
- P10275; P27540; P49407; O00257; Q92793; Q6S7F2; Q5RIX9; Q96CJ1; Q9GZT9; Q96KS0; Q9H6Z9; Q09472; Q9NWT6; Q92831; Q13330; Q13438; Q8N2W9; P14618-1; Q8BIF2; P51450-2; Q9UHD8-1; P08047; P63165; O94888; P40818; P40337
Publication
- PubMed ID:
- 7539918 9079689 9782081 18638657 12508121 15489334 8917528 9235919 9822602 9653127 10202154 9887100 11006129 10944113 10594042 10758161 11566883 11389899 11292861 12464182 12080085 12351678 12914934 12560087 12778114 15465032 14757845 15776016 16288748 16543236 16973622 17610843 17956732 17244529 16862177 18658046 18809331 19046997 19528298 20624928 20889502 20699359 22537386 22009797 22128162 22286099 23469069 24681946 25974097 11089639 12446723 11959990 11959977 12004076 12050673