Names & Taxonomy
- Uniprot ID:
- Q16651
- Entry Name:
- PRSS8_HUMAN
- Status:
- reviewed
- Protein Names:
- Prostasin (EC 3.4.21.-) (Channel-activating protease 1) (CAP1) (Serine protease 8) [Cleaved into: Prostasin light chain; Prostasin heavy chain]
- Gene Names:
- PRSS8
- Gene Names Primary:
- PRSS8
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 343
- Sequence:
- MAQKGVLGPGQLGAVAILLYLGLLRSGTGAEGAEAPCGVAPQARITGGSSAVAGQWPWQVSITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKEAYEVKLGAHQLDSYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLSRPITFSRYIRPICLPAANASFPNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLISRETCNCLYNIDAKPEEPHFVQEDMVCAGYVEGGKDACQGDSGGPLSCPVEGLWYLTGIVSWGDACGARNRPGVYTLASSYASWIQSKVTELQPRVVPQTQESQPDSNLCGSHLAFSSAPAQGLLRPILFLPLGLALGLLSPWLSEH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Prostasin: Cell membrane; Single-pass membrane protein.; Prostasin light chain: Secreted, extracellular space. Note=Found in the seminal fluid. Secreted after cleavage of its C-terminus.; Prostasin heavy chain: Secreted, extracellular space. Note=Found in the seminal fluid. Secreted after cleavage of its C-terminus.
Function
- Function:
- Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G).
- Active Site:
- ACT_SITE 85 85 Charge relay system.; ACT_SITE 134 134 Charge relay system.; ACT_SITE 238 238 Charge relay system.
- Gene Ontology Go:
- extracellular exosome
extracellular region
extracellular space
integral component of membrane
plasma membrane
serine-type endopeptidase activity
serine-type peptidase activity - Gene Ontology Molecular Function:
- serine-type endopeptidase activity
serine-type peptidase activity - Gene Ontology Cellular Component:
- extracellular exosome
extracellular region
extracellular space
integral component of membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Hydrolase
Membrane
Protease
Reference proteome
Secreted
Serine protease
Signal
Transmembrane
Transmembrane helix
Zymogen