Names & Taxonomy
- Uniprot ID:
- Q15796
- Entry Name:
- SMAD2_HUMAN
- Status:
- reviewed
- Protein Names:
- Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)
- Gene Names:
- SMAD2 MADH2 MADR2
- Gene Names Primary:
- SMAD2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 467
- Sequence:
- MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKTGRLDELEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQSMDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
- Gene Ontology Go:
- activin responsive factor complex
cytoplasm
cytosol
nuclear chromatin
nucleoplasm
nucleus
SMAD protein complex
SMAD2-SMAD3 protein complex
transcription factor complex
activating transcription factor binding
chromatin binding
co-SMAD binding
double-stranded DNA binding
enhancer binding
I-SMAD binding
metal ion binding
phosphatase binding
R-SMAD binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
SMAD binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transforming growth factor beta receptor binding
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
type I transforming growth factor beta receptor binding
ubiquitin protein ligase binding
activin receptor signaling pathway
anterior/posterior pattern specification
cell fate commitment
common-partner SMAD protein phosphorylation
embryonic cranial skeleton morphogenesis
embryonic foregut morphogenesis
endoderm formation
gastrulation
gene expression
in utero embryonic development
insulin secretion
intracellular signal transduction
lung development
mesoderm formation
negative regulation of cell proliferation
negative regulation of transcription from RNA polymerase II promoter
negative regulation of transcription, DNA-templated
negative regulation of transforming growth factor beta receptor signaling pathway
nodal signaling pathway
organ growth
palate development
pancreas development
paraxial mesoderm morphogenesis
pericardium development
positive regulation of BMP signaling pathway
positive regulation of epithelial to mesenchymal transition
positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
post-embryonic development
primary miRNA processing
regulation of binding
regulation of transforming growth factor beta receptor signaling pathway
response to cholesterol
response to glucose
signal transduction involved in regulation of gene expression
SMAD protein complex assembly
SMAD protein signal transduction
somatic stem cell population maintenance
transcription initiation from RNA polymerase II promoter
transcription, DNA-templated
transforming growth factor beta receptor signaling pathway
ureteric bud development
zygotic specification of dorsal/ventral axis - Gene Ontology Biological Process:
- activin receptor signaling pathway
anterior/posterior pattern specification
cell fate commitment
common-partner SMAD protein phosphorylation
embryonic cranial skeleton morphogenesis
embryonic foregut morphogenesis
endoderm formation
gastrulation
gene expression
insulin secretion
intracellular signal transduction
in utero embryonic development
lung development
mesoderm formation
negative regulation of cell proliferation
negative regulation of transcription, DNA-templated
negative regulation of transcription from RNA polymerase II promoter
negative regulation of transforming growth factor beta receptor signaling pathway
nodal signaling pathway
organ growth
palate development
pancreas development
paraxial mesoderm morphogenesis
pericardium development
positive regulation of BMP signaling pathway
positive regulation of epithelial to mesenchymal transition
positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
post-embryonic development
primary miRNA processing
regulation of binding
regulation of transforming growth factor beta receptor signaling pathway
response to cholesterol
response to glucose
signal transduction involved in regulation of gene expression
SMAD protein complex assembly
SMAD protein signal transduction
somatic stem cell population maintenance
transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
transforming growth factor beta receptor signaling pathway
ureteric bud development
zygotic specification of dorsal/ventral axis - Gene Ontology Molecular Function:
- activating transcription factor binding
chromatin binding
co-SMAD binding
double-stranded DNA binding
enhancer binding
I-SMAD binding
metal ion binding
phosphatase binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
R-SMAD binding
SMAD binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
transforming growth factor beta receptor binding
type I transforming growth factor beta receptor binding
ubiquitin protein ligase binding - Gene Ontology Cellular Component:
- activin responsive factor complex
cytoplasm
cytosol
nuclear chromatin
nucleoplasm
nucleus
SMAD2-SMAD3 protein complex
SMAD protein complex
transcription factor complex - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
DNA-binding
Direct protein sequencing
Metal-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Transcription
Transcription regulation
Ubl conjugation
Zinc - Interacts With:
- Q12955; P05060; P98082; Q9BZ29; P70056; P05412; Q9NYA4; P07197; Q8TAK6; P35813; Q9H6Z4; P61586; P84022; Q13485; Q9HAU4; Q13573; P04637; Q9H3D4; Q9UPN9; O00308; Q96KR1; O95405
Publication
- PubMed ID:
- 8673135 8774881 8752209 9389648 9503010 15489334 8980228 9865696 9670020 9873005 9136927 9346908 9702198 9892009 11387212 11278756 11389444 11879191 12193595 15601644 15647271 16200078 16751101 16751102 17074756 17099224 17327236 17292623 16862174 18691976 18568018 18669648 19413330 19289081 19049980 20129061 20068231 21269460 21599657 21947082 22781750 22223895 22814378 23478445 24324267 24627487 9759503 10647776 10708948 10708949 25105025 10615055 15350224 16959974