Names & Taxonomy
- Uniprot ID:
- Q15375
- Entry Name:
- EPHA7_HUMAN
- Status:
- reviewed
- Protein Names:
- Ephrin type-A receptor 7 (EC 2.7.10.1) (EPH homology kinase 3) (EHK-3) (EPH-like kinase 11) (EK11) (hEK11)
- Gene Names:
- EPHA7 EHK3 HEK11
- Gene Names Primary:
- EPHA7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 998
- Sequence:
- MVFQTRYPSWIILCYIWLLRFAHTGEAQAAKEVLLLDSKAQQTELEWISSPPNGWEEISGLDENYTPIRTYQVCQVMEPNQNNWLRTNWISKGNAQRIFVELKFTLRDCNSLPGVLGTCKETFNLYYYETDYDTGRNIRENLYVKIDTIAADESFTQGDLGERKMKLNTEVREIGPLSKKGFYLAFQDVGACIALVSVKVYYKKCWSIIENLAIFPDTVTGSEFSSLVEVRGTCVSSAEEEAENAPRMHCSAEGEWLVPIGKCICKAGYQQKGDTCEPCGRGFYKSSSQDLQCSRCPTHSFSDKEGSSRCECEDGYYRAPSDPPYVACTRPPSAPQNLIFNINQTTVSLEWSPPADNGGRNDVTYRILCKRCSWEQGECVPCGSNIGYMPQQTGLEDNYVTVMDLLAHANYTFEVEAVNGVSDLSRSQRLFAAVSITTGQAAPSQVSGVMKERVLQRSVELSWQEPEHPNGVITEYEIKYYEKDQRERTYSTVKTKSTSASINNLKPGTVYVFQIRAFTAAGYGNYSPRLDVATLEEATGKMFEATAVSSEQNPVIIIAVVAVAGTIILVFMVFGFIIGRRHCGYSKADQEGDEELYFHFKFPGTKTYIDPETYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERAERPKFEQIVGILDKMIRNPNSLKTPLGTCSRPISPLLDQNTPDFTTFCSVGEWLQAIKMERYKDNFTAAGYNSLESVARMTIEDVMSLGITLVGHQKKIMSSIQTMRAQMLHLHGTGIQV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.
- Catalytic Activity:
- ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
- Active Site:
- ACT_SITE 758 758 Proton acceptor.
- Gene Ontology Go:
- dendrite
integral component of plasma membrane
neuromuscular junction
neuronal cell body
plasma membrane
postsynaptic membrane
ATP binding
axon guidance receptor activity
chemorepellent activity
GPI-linked ephrin receptor activity
protein tyrosine kinase activity
axon guidance
brain development
branching morphogenesis of a nerve
ephrin receptor signaling pathway
negative chemotaxis
negative regulation of collateral sprouting
negative regulation of synapse assembly
nephric duct morphogenesis
phosphorylation
positive regulation of neuron apoptotic process
positive regulation of protein phosphorylation
regulation of cell-cell adhesion
regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of ERK1 and ERK2 cascade
regulation of peptidyl-tyrosine phosphorylation
regulation of protein autophosphorylation
retinal ganglion cell axon guidance - Gene Ontology Biological Process:
- axon guidance
brain development
branching morphogenesis of a nerve
ephrin receptor signaling pathway
negative chemotaxis
negative regulation of collateral sprouting
negative regulation of synapse assembly
nephric duct morphogenesis
phosphorylation
positive regulation of neuron apoptotic process
positive regulation of protein phosphorylation
regulation of cell-cell adhesion
regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of ERK1 and ERK2 cascade
regulation of peptidyl-tyrosine phosphorylation
regulation of protein autophosphorylation
retinal ganglion cell axon guidance - Gene Ontology Molecular Function:
- ATP binding
axon guidance receptor activity
chemorepellent activity
GPI-linked ephrin receptor activity
protein tyrosine kinase activity - Gene Ontology Cellular Component:
- dendrite
integral component of plasma membrane
neuromuscular junction
neuronal cell body
plasma membrane
postsynaptic membrane - Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Apoptosis
Cell membrane
Complete proteome
Developmental protein
Glycoprotein
Kinase
Membrane
Neurogenesis
Nucleotide-binding
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transferase
Transmembrane
Transmembrane helix
Tyrosine-protein kinase - Interacts With:
- P52793; P29317