Names & Taxonomy
- Uniprot ID:
- Q15034
- Entry Name:
- HERC3_HUMAN
- Status:
- reviewed
- Protein Names:
- Probable E3 ubiquitin-protein ligase HERC3 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 3)
- Gene Names:
- HERC3 KIAA0032
- Gene Names Primary:
- HERC3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1050
- Sequence:
- MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKGYWAAHSGQLSARADRFKYHIVKQIFSGGDQTFVLCSKYENYSPAVDFRTMNQAHYTSLINDETIAVWRQKLSEHNNANTINGVVQILSSAACWNGSFLEKKIDEHFKTSPKIPGIDLNSTRVLFEKLMNSQHSMILEQILNSFESCLIPQLSSSPPDVEAMRIYLILPEFPLLQDSKYYITLTIPLAMAILRLDTNPSKVLDNWWSQVCPKYFMKLVNLYKGAVLYLLRGRKTFLIPVLFNNYITAALKLLEKLYKVNLKVKHVEYDTFYIPEISNLVDIQEDYLMWFLHQAGMKARPSIIQDTVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPLLARSPFLVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFVEHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGFSLA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Cytoplasmic vesicle. Note=Also found in vesicular-like structures.
Function
- Function:
- E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
- Pathway:
- Protein modification; protein ubiquitination.
- Active Site:
- ACT_SITE 1018 1018 Glycyl thioester intermediate.
- Gene Ontology Go:
- cytoplasmic, membrane-bounded vesicle
ligase activity
ubiquitin-protein transferase activity
protein ubiquitination involved in ubiquitin-dependent protein catabolic process - Gene Ontology Biological Process:
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- Gene Ontology Molecular Function:
- ligase activity
ubiquitin-protein transferase activity - Gene Ontology Cellular Component:
- cytoplasmic, membrane-bounded vesicle
- Keywords:
- Alternative splicing
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Ligase
Polymorphism
Reference proteome
Repeat
Ubl conjugation
Ubl conjugation pathway