Names & Taxonomy
- Uniprot ID:
- Q14831
- Entry Name:
- GRM7_HUMAN
- Status:
- reviewed
- Protein Names:
- Metabotropic glutamate receptor 7 (mGluR7)
- Gene Names:
- GRM7 GPRC1G MGLUR7
- Gene Names Primary:
- GRM7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 915
- Sequence:
- MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNSPAAKKKYVSYNNLVI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
- Gene Ontology Go:
- asymmetric synapse
axon
cell cortex
dendrite
dendritic shaft
integral component of membrane
integral component of plasma membrane
plasma membrane
postsynaptic membrane
presynaptic active zone
presynaptic membrane
receptor complex
adenylate cyclase inhibitor activity
calcium channel regulator activity
calcium ion binding
glutamate binding
glutamate receptor activity
group III metabotropic glutamate receptor activity
PDZ domain binding
serine binding
voltage-gated calcium channel activity
adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
adult behavior
conditioned taste aversion
multicellular organismal response to stress
negative regulation of adenylate cyclase activity
negative regulation of cAMP biosynthetic process
negative regulation of glutamate secretion
regulation of cyclase activity
sensory perception of smell
sensory perception of sound
short-term memory
synaptic transmission
transmission of nerve impulse - Gene Ontology Biological Process:
- adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
adult behavior
conditioned taste aversion
multicellular organismal response to stress
negative regulation of adenylate cyclase activity
negative regulation of cAMP biosynthetic process
negative regulation of glutamate secretion
regulation of cyclase activity
sensory perception of smell
sensory perception of sound
short-term memory
synaptic transmission
transmission of nerve impulse - Gene Ontology Molecular Function:
- adenylate cyclase inhibitor activity
calcium channel regulator activity
calcium ion binding
glutamate binding
glutamate receptor activity
group III metabotropic glutamate receptor activity
PDZ domain binding
serine binding
voltage-gated calcium channel activity - Gene Ontology Cellular Component:
- asymmetric synapse
axon
cell cortex
dendrite
dendritic shaft
integral component of membrane
integral component of plasma membrane
plasma membrane
postsynaptic membrane
presynaptic active zone
presynaptic membrane
receptor complex - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Olfaction
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Sensory transduction
Signal
Transducer
Transmembrane
Transmembrane helix