Names & Taxonomy
- Uniprot ID:
- Q10588
- Entry Name:
- BST1_HUMAN
- Status:
- reviewed
- Protein Names:
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (EC 3.2.2.6) (ADP-ribosyl cyclase 2) (Bone marrow stromal antigen 1) (BST-1) (Cyclic ADP-ribose hydrolase 2) (cADPr hydrolase 2) (CD antigen CD157)
- Gene Names:
- BST1
- Gene Names Primary:
- BST1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 318
- Sequence:
- MAAQGCAASRLLQLLLQLLLLLLLLAAGGARARWRGEGTSAHLRDIFLGRCAEYRALLSPEQRNKNCTAIWEAFKVALDKDPCSVLPSDYDLFINLSRHSIPRDKSLFWENSHLLVNSFADNTRRFMPLSDVLYGRVADFLSWCRQKNDSGLDYQSCPTSEDCENNPVDSFWKRASIQYSKDSSGVIHVMLNGSEPTGAYPIKGFFADYEIPNLQKEKITRIEIWVMHEIGGPNVESCGEGSMKVLEKRLKDMGFQYSCINDYRPVKLLQCVDHSTHPDCALKSAAAATQRKAPSLYTEQRAGLIIPLFLVLASRTQL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Lipid-anchor, GPI-anchor.
Function
- Function:
- Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.
- Catalytic Activity:
- NAD(+) + H(2)O = ADP-D-ribose + nicotinamide.
- Cross Reference Drug Bank:
- DB02701
- Gene Ontology Go:
- anchored component of membrane
extracellular exosome
extrinsic component of membrane
plasma membrane
NAD(P)+ nucleosidase activity
NAD+ nucleosidase activity
phosphorus-oxygen lyase activity
transferase activity
humoral immune response
multicellular organism development
positive regulation of B cell proliferation - Gene Ontology Biological Process:
- humoral immune response
multicellular organism development
positive regulation of B cell proliferation - Gene Ontology Molecular Function:
- NAD(P)+ nucleosidase activity
NAD+ nucleosidase activity
phosphorus-oxygen lyase activity
transferase activity - Gene Ontology Cellular Component:
- anchored component of membrane
extracellular exosome
extrinsic component of membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
GPI-anchor
Glycoprotein
Hydrolase
Lipoprotein
Membrane
NAD
NADP
Polymorphism
Reference proteome
Signal
Transferase