Names & Taxonomy
- Uniprot ID:
- Q08257
- Entry Name:
- QOR_HUMAN
- Status:
- reviewed
- Protein Names:
- Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta-crystallin)
- Gene Names:
- CRYZ
- Gene Names Primary:
- CRYZ
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 329
- Sequence:
- MATGQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMILLL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding.
- Catalytic Activity:
- NADPH + 2 quinone = NADP(+) + 2 semiquinone.
- Cross Reference Drug Bank:
- DB00266
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
mRNA 3'-UTR binding
NADPH binding
NADPH:quinone reductase activity
zinc ion binding
protein homotetramerization
visual perception
xenobiotic catabolic process - Gene Ontology Biological Process:
- protein homotetramerization
visual perception
xenobiotic catabolic process - Gene Ontology Molecular Function:
- mRNA 3'-UTR binding
NADPH:quinone reductase activity
NADPH binding
zinc ion binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
NADP
Oxidoreductase
Phosphoprotein
Polymorphism
RNA-binding
Reference proteome