Names & Taxonomy
- Uniprot ID:
- Q01740
- Entry Name:
- FMO1_HUMAN
- Status:
- reviewed
- Protein Names:
- Dimethylaniline monooxygenase [N-oxide-forming] 1 (EC 1.14.13.8) (Dimethylaniline oxidase 1) (Fetal hepatic flavin-containing monooxygenase 1) (FMO 1)
- Gene Names:
- FMO1
- Gene Names Primary:
- FMO1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 532
- Sequence:
- MAKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRFTEHVEEGRASLYKSVVSNSCKEMSCYSDFPFPEDYPNYVPNSQFLEYLKMYANHFDLLKHIQFKTKVCSVTKCSDSAVSGQWEVVTMHEEKQESAIFDAVMVCTGFLTNPYLPLDSFPGINAFKGQYFHSRQYKHPDIFKDKRVLVIGMGNSGTDIAVEASHLAEKVFLSTTGGGWVISRIFDSGYPWDMVFMTRFQNMLRNSLPTPIVTWLMERKINNWLNHANYGLIPEDRTQLKEFVLNDELPGRIITGKVFIRPSIKEVKENSVIFNNTSKEEPIDIIVFATGYTFAFPFLDESVVKVEDGQASLYKYIFPAHLQKPTLAIIGLIKPLGSMIPTGETQARWAVRVLKGVNKLPPPSVMIEEINARKENKPSWFGLCYCKALQSDYITYIDELLTYINAKPNLFSMLLTDPHLALTVFFGPCSPYQFRLTGPGKWEGARNAIMTQWDRTFKVIKARVVQESPSPFESFLKVFSFLALLVAIFLIFL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Microsome membrane. Endoplasmic reticulum membrane.
Function
- Function:
- This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.
- Catalytic Activity:
- N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O.
- Cofactor:
- COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692;
- Cross Reference Drug Bank:
- DB00185 DB00501 DB04871 DB00675 DB05294 DB00582
- Gene Ontology Go:
- endoplasmic reticulum lumen
endoplasmic reticulum membrane
integral component of membrane
flavin adenine dinucleotide binding
monooxygenase activity
N,N-dimethylaniline monooxygenase activity
NADP binding
drug metabolic process
NADPH oxidation
organic acid metabolic process
response to lipopolysaccharide
response to osmotic stress
small molecule metabolic process
toxin metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- drug metabolic process
NADPH oxidation
organic acid metabolic process
response to lipopolysaccharide
response to osmotic stress
small molecule metabolic process
toxin metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- flavin adenine dinucleotide binding
monooxygenase activity
N,N-dimethylaniline monooxygenase activity
NADP binding - Gene Ontology Cellular Component:
- endoplasmic reticulum lumen
endoplasmic reticulum membrane
integral component of membrane - Keywords:
- Acetylation
Alternative splicing
Complete proteome
Endoplasmic reticulum
FAD
Flavoprotein
Membrane
Microsome
Monooxygenase
NADP
Oxidoreductase
Polymorphism
Reference proteome
Transmembrane