Names & Taxonomy
- Uniprot ID:
- P68032
- Entry Name:
- ACTC_HUMAN
- Status:
- reviewed
- Protein Names:
- Actin, alpha cardiac muscle 1 (Alpha-cardiac actin)
- Gene Names:
- ACTC1 ACTC
- Gene Names Primary:
- ACTC1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 377
- Sequence:
- MCDDEETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytoskeleton.
Function
- Function:
- Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
- Gene Ontology Go:
- actin filament
actomyosin, actin portion
blood microparticle
cell body
cytoplasm
cytosol
extracellular exosome
extracellular space
filopodium
focal adhesion
I band
lamellipodium
membrane
sarcomere
ATP binding
ATPase activity
myosin binding
actin filament-based movement
actin-myosin filament sliding
actomyosin structure organization
apoptotic process
cardiac muscle contraction
cardiac muscle tissue morphogenesis
cardiac myofibril assembly
heart contraction
mesenchyme migration
muscle filament sliding
negative regulation of apoptotic process
positive regulation of gene expression
response to drug
response to ethanol
skeletal muscle thin filament assembly - Gene Ontology Biological Process:
- actin filament-based movement
actin-myosin filament sliding
actomyosin structure organization
apoptotic process
cardiac muscle contraction
cardiac muscle tissue morphogenesis
cardiac myofibril assembly
heart contraction
mesenchyme migration
muscle filament sliding
negative regulation of apoptotic process
positive regulation of gene expression
response to drug
response to ethanol
skeletal muscle thin filament assembly - Gene Ontology Molecular Function:
- ATPase activity
ATP binding
myosin binding - Gene Ontology Cellular Component:
- actin filament
actomyosin, actin portion
blood microparticle
cell body
cytoplasm
cytosol
extracellular exosome
extracellular space
filopodium
focal adhesion
I band
lamellipodium
membrane
sarcomere - Keywords:
- ATP-binding
Atrial septal defect
Cardiomyopathy
Complete proteome
Cytoplasm
Cytoskeleton
Disease mutation
Isopeptide bond
Methylation
Muscle protein
Nucleotide-binding
Oxidation
Reference proteome