Names & Taxonomy
- Uniprot ID:
- P62913
- Entry Name:
- RL11_HUMAN
- Status:
- reviewed
- Protein Names:
- 60S ribosomal protein L11 (CLL-associated antigen KW-12)
- Gene Names:
- RPL11
- Gene Names Primary:
- RPL11
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 178
- Sequence:
- MAQDQGEKENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVRSFGIRRNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGFGIQEHIDLGIKYDPSIGIYGLDFYVVLGRPGFSIADKKRRTGCIGAKHRISKEEAMRWFQQKYDGIILPGK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus, nucleolus
Function
- Function:
- Binds to 5S ribosomal RNA (By similarity). Required for rRNA maturation and formation of the 60S ribosomal subunits. Promotes nucleolar location of PML (By similarity).
- Gene Ontology Go:
- cytoplasm
cytosol
cytosolic large ribosomal subunit
extracellular exosome
membrane
nucleolus
poly(A) RNA binding
RNA binding
rRNA binding
structural constituent of ribosome
cellular nitrogen compound metabolic process
cellular protein metabolic process
gene expression
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
protein localization to nucleus
protein targeting
ribosomal large subunit assembly
ribosomal large subunit biogenesis
rRNA processing
selenium compound metabolic process
selenocysteine metabolic process
small molecule metabolic process
SRP-dependent cotranslational protein targeting to membrane
translation
translational elongation
translational initiation
translational termination
viral life cycle
viral process
viral transcription - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
cellular protein metabolic process
gene expression
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
protein localization to nucleus
protein targeting
ribosomal large subunit assembly
ribosomal large subunit biogenesis
rRNA processing
selenium compound metabolic process
selenocysteine metabolic process
small molecule metabolic process
SRP-dependent cotranslational protein targeting to membrane
translation
translational elongation
translational initiation
translational termination
viral life cycle
viral process
viral transcription - Gene Ontology Molecular Function:
- poly(A) RNA binding
RNA binding
rRNA binding
structural constituent of ribosome - Gene Ontology Cellular Component:
- cytoplasm
cytosol
cytosolic large ribosomal subunit
extracellular exosome
membrane
nucleolus - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Diamond-Blackfan anemia
Direct protein sequencing
Disease mutation
Nucleus
Phosphoprotein
RNA-binding
Reference proteome
Ribonucleoprotein
Ribosomal protein
rRNA-binding - Interacts With:
- Q13554; Q6A162; P60409; Q00987; P01106; Q15843