Names & Taxonomy
- Uniprot ID:
- P62736
- Entry Name:
- ACTA_HUMAN
- Status:
- reviewed
- Protein Names:
- Actin, aortic smooth muscle (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein)
- Gene Names:
- ACTA2 ACTSA ACTVS GIG46
- Gene Names Orf:
- GIG46
- Gene Names Primary:
- ACTA2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 377
- Sequence:
- MCEEEDSTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytoskeleton.
Function
- Function:
- Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
- Gene Ontology Go:
- actin cytoskeleton
cell body
cytoplasm
cytosol
extracellular exosome
extracellular space
filopodium
lamellipodium
protein complex
smooth muscle contractile fiber
ATP binding
protein kinase binding
glomerular mesangial cell development
mesenchyme migration
muscle contraction
positive regulation of gene expression
regulation of blood pressure
response to virus
vascular smooth muscle contraction - Gene Ontology Biological Process:
- glomerular mesangial cell development
mesenchyme migration
muscle contraction
positive regulation of gene expression
regulation of blood pressure
response to virus
vascular smooth muscle contraction - Gene Ontology Molecular Function:
- ATP binding
protein kinase binding - Gene Ontology Cellular Component:
- actin cytoskeleton
cell body
cytoplasm
cytosol
extracellular exosome
extracellular space
filopodium
lamellipodium
protein complex
smooth muscle contractile fiber - Keywords:
- ATP-binding
Acetylation
Aortic aneurysm
Complete proteome
Cytoplasm
Cytoskeleton
Disease mutation
Isopeptide bond
Methylation
Muscle protein
Nucleotide-binding
Oxidation
Polymorphism
Reference proteome