Names & Taxonomy
- Uniprot ID:
- P51589
- Entry Name:
- CP2J2_HUMAN
- Status:
- reviewed
- Protein Names:
- Cytochrome P450 2J2 (EC 1.14.14.1) (Arachidonic acid epoxygenase) (CYPIIJ2)
- Gene Names:
- CYP2J2
- Gene Names Primary:
- CYP2J2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 502
- Sequence:
- MLAAMGSLAAALWAVVHPRTLLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFRMGITISPVSHRLCAVPQV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Function
- Function:
- This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools.
- Catalytic Activity:
- RH + + O(2) = ROH + + H(2)O.
- Cofactor:
- COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
- Cross Reference Drug Bank:
- DB06605 DB00637 DB00169 DB08918 DB00179 DB06228
- Gene Ontology Go:
- endoplasmic reticulum membrane
extracellular exosome
arachidonic acid 11,12-epoxygenase activity
arachidonic acid 14,15-epoxygenase activity
arachidonic acid epoxygenase activity
aromatase activity
heme binding
iron ion binding
linoleic acid epoxygenase activity
steroid hydroxylase activity
arachidonic acid metabolic process
epoxygenase P450 pathway
icosanoid metabolic process
linoleic acid metabolic process
regulation of heart contraction
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- arachidonic acid metabolic process
epoxygenase P450 pathway
icosanoid metabolic process
linoleic acid metabolic process
regulation of heart contraction
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- arachidonic acid 11,12-epoxygenase activity
arachidonic acid 14,15-epoxygenase activity
arachidonic acid epoxygenase activity
aromatase activity
heme binding
iron ion binding
linoleic acid epoxygenase activity
steroid hydroxylase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
extracellular exosome - Keywords:
- Complete proteome
Direct protein sequencing
Endoplasmic reticulum
Heme
Iron
Membrane
Metal-binding
Microsome
Monooxygenase
NADP
Oxidoreductase
Polymorphism
Reference proteome