Names & Taxonomy
- Uniprot ID:
- P50607
- Entry Name:
- TUB_HUMAN
- Status:
- reviewed
- Protein Names:
- Tubby protein homolog
- Gene Names:
- TUB
- Gene Names Primary:
- TUB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 506
- Sequence:
- MTSKPHSDWIPYSVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVDVEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFDSKLACE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.
- Gene Ontology Go:
- cilium
cytoplasm
cytosol
extracellular region
nucleus
plasma membrane
phosphatidylinositol binding
protein complex binding
phagocytosis, recognition
photoreceptor cell maintenance
positive regulation of phagocytosis
protein localization to photoreceptor outer segment
receptor localization to nonmotile primary cilium
response to hormone
retina development in camera-type eye
sensory perception of sound - Gene Ontology Biological Process:
- phagocytosis, recognition
photoreceptor cell maintenance
positive regulation of phagocytosis
protein localization to photoreceptor outer segment
receptor localization to nonmotile primary cilium
response to hormone
retina development in camera-type eye
sensory perception of sound - Gene Ontology Molecular Function:
- phosphatidylinositol binding
protein complex binding - Gene Ontology Cellular Component:
- cilium
cytoplasm
cytosol
extracellular region
nucleus
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Cytoplasm
Membrane
Nucleus
Obesity
Phagocytosis
Reference proteome
Secreted
Sensory transduction