Names & Taxonomy
- Uniprot ID:
- P49763
- Entry Name:
- PLGF_HUMAN
- Status:
- reviewed
- Protein Names:
- Placenta growth factor (PlGF)
- Gene Names:
- PGF PGFL PLGF
- Gene Names Primary:
- PGF
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 221
- Sequence:
- MPVMRLFPCFLQLLAGLALPAVPPQQWALSAGNGSSEVEVVPFQEVWGRSYCRALERLVDVVSEYPSEVEHMFSPSCVSLLRCTGCCGDENLHCVPVETANVTMQLLKIRSGDRPSYVELTFSQHVRCECRHSPGRQSPDMPGDFRADAPSFLPPRRSLPMLFRMEWGCALTGSQSAVWPSSPVPEEIPRMHPGRNGKKQQRKPLREKMKPERCGDAVPRR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted. Note=The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.
Function
- Function:
- Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.
- Cross Reference Drug Bank:
- DB08885
- Gene Ontology Go:
- extracellular region
extracellular space
membrane
growth factor activity
heparin binding
branching involved in ureteric bud morphogenesis
cell differentiation
cell-cell signaling
cellular response to hormone stimulus
female pregnancy
organ regeneration
positive regulation of angiogenesis
positive regulation of cell division
positive regulation of cell proliferation
positive regulation of endothelial cell proliferation
regulation of morphogenesis of a branching structure
response to drug
response to hypoxia
signal transduction
sprouting angiogenesis
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Biological Process:
- branching involved in ureteric bud morphogenesis
cell-cell signaling
cell differentiation
cellular response to hormone stimulus
female pregnancy
organ regeneration
positive regulation of angiogenesis
positive regulation of cell division
positive regulation of cell proliferation
positive regulation of endothelial cell proliferation
regulation of morphogenesis of a branching structure
response to drug
response to hypoxia
signal transduction
sprouting angiogenesis
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Molecular Function:
- growth factor activity
heparin binding - Gene Ontology Cellular Component:
- extracellular region
extracellular space
membrane - Keywords:
- 3D-structure
Alternative splicing
Angiogenesis
Complete proteome
Developmental protein
Differentiation
Direct protein sequencing
Disulfide bond
Glycoprotein
Growth factor
Heparin-binding
Mitogen
Reference proteome
Secreted
Signal - Interacts With:
- P17948