Names & Taxonomy
- Uniprot ID:
- P49411
- Entry Name:
- EFTU_HUMAN
- Status:
- reviewed
- Protein Names:
- Elongation factor Tu, mitochondrial (EF-Tu) (P43)
- Gene Names:
- TUFM
- Gene Names Primary:
- TUFM
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 452
- Sequence:
- MAAATLLRATPHFSGLAAGRTFLLQGLLRLLKAPALPLLCRGLAVEAKKTYVRDKPHVNVGTIGHVDHGKTTLTAAITKILAEGGGAKFKKYEEIDNAPEERARGITINAAHVEYSTAARHYAHTDCPGHADYVKNMITGTAPLDGCILVVAANDGPMPQTREHLLLARQIGVEHVVVYVNKADAVQDSEMVELVELEIRELLTEFGYKGEETPVIVGSALCALEGRDPELGLKSVQKLLDAVDTYIPVPARDLEKPFLLPVEAVYSVPGRGTVVTGTLERGILKKGDECELLGHSKNIRTVVTGIEMFHKSLERAEAGDNLGALVRGLKREDLRRGLVMVKPGSIKPHQKVEAQVYILSKEEGGRHKPFVSHFMPVMFSLTWDMACRIILPPEKELAMPGEDLKFNLILRQPMILEKGQRFTLRDGNRTIGTGLVTNTLAMTEEEKNIKWG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion.
Function
- Function:
- This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
- Gene Ontology Go:
- extracellular exosome
membrane
mitochondrial nucleoid
mitochondrion
GTP binding
GTPase activity
poly(A) RNA binding
translation elongation factor activity
mitochondrial translation
mitochondrial translational elongation
organelle organization
translational elongation - Gene Ontology Biological Process:
- mitochondrial translation
mitochondrial translational elongation
organelle organization
translational elongation - Gene Ontology Molecular Function:
- GTPase activity
GTP binding
poly(A) RNA binding
translation elongation factor activity - Gene Ontology Cellular Component:
- extracellular exosome
membrane
mitochondrial nucleoid
mitochondrion - Keywords:
- Acetylation
Complete proteome
Direct protein sequencing
Disease mutation
Elongation factor
GTP-binding
Mitochondrion
Nucleotide-binding
Protein biosynthesis
Reference proteome
Transit peptide - Interacts With:
- Q15041; Q96DZ9; Q8IZU0; Q8IVP5