Names & Taxonomy
- Uniprot ID:
- P49146
- Entry Name:
- NPY2R_HUMAN
- Status:
- reviewed
- Protein Names:
- Neuropeptide Y receptor type 2 (NPY2-R) (NPY-Y2 receptor) (Y2 receptor)
- Gene Names:
- NPY2R
- Gene Names Primary:
- NPY2R
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 381
- Sequence:
- MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > PP > NPY > PP, PYY and NPY free acid.
- Cross Reference Drug Bank:
- DB00847
- Gene Ontology Go:
- cytosol
integral component of plasma membrane
nonmotile primary cilium
plasma membrane
calcium channel regulator activity
neuropeptide Y receptor activity
peptide YY receptor activity
receptor activity
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
behavioral fear response
cardiac left ventricle morphogenesis
cell surface receptor signaling pathway
feeding behavior
locomotory behavior
negative regulation of cAMP biosynthetic process
negative regulation of excitatory postsynaptic potential
negative regulation of feeding behavior
negative regulation of neurological system process
negative regulation of secretion
negative regulation of synaptic transmission, glutamatergic
nitric oxide mediated signal transduction
outflow tract morphogenesis
positive regulation of cell-substrate adhesion
positive regulation of circadian sleep/wake cycle, non-REM sleep
positive regulation of cytosolic calcium ion concentration
positive regulation of dopamine secretion
positive regulation of peptide secretion
positive regulation of smooth muscle contraction
regulation of sensory perception of pain
secretion - Gene Ontology Biological Process:
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
behavioral fear response
cardiac left ventricle morphogenesis
cell surface receptor signaling pathway
feeding behavior
locomotory behavior
negative regulation of cAMP biosynthetic process
negative regulation of excitatory postsynaptic potential
negative regulation of feeding behavior
negative regulation of neurological system process
negative regulation of secretion
negative regulation of synaptic transmission, glutamatergic
nitric oxide mediated signal transduction
outflow tract morphogenesis
positive regulation of cell-substrate adhesion
positive regulation of circadian sleep/wake cycle, non-REM sleep
positive regulation of cytosolic calcium ion concentration
positive regulation of dopamine secretion
positive regulation of peptide secretion
positive regulation of smooth muscle contraction
regulation of sensory perception of pain
secretion - Gene Ontology Molecular Function:
- calcium channel regulator activity
neuropeptide Y receptor activity
peptide YY receptor activity
receptor activity - Gene Ontology Cellular Component:
- cytosol
integral component of plasma membrane
nonmotile primary cilium
plasma membrane - Keywords:
- 3D-structure
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix - Interacts With:
- P10082