Names & Taxonomy
- Uniprot ID:
- P48728
- Entry Name:
- GCST_HUMAN
- Status:
- reviewed
- Protein Names:
- Aminomethyltransferase, mitochondrial (EC 2.1.2.10) (Glycine cleavage system T protein) (GCVT)
- Gene Names:
- AMT GCST
- Gene Names Primary:
- AMT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 403
- Sequence:
- MQRAVSVVARLGFRLQAFPPALCRPLSCAQEVLRRTPLYDFHLAHGGKMVAFAGWSLPVQYRDSHTDSHLHTRQHCSLFDVSHMLQTKILGSDRVKLMESLVVGDIAELRPNQGTLSLFTNEAGGILDDLIVTNTSEGHLYVVSNAGCWEKDLALMQDKVRELQNQGRDVGLEVLDNALLALQGPTAAQVLQAGVADDLRKLPFMTSAVMEVFGVSGCRVTRCGYTGEDGVEISVPVAGAVHLATAILKNPEVKLAGLAARDSLRLEAGLCLYGNDIDEHTTPVEGSLSWTLGKRRRAAMDFPGAKVIVPQLKGRVQRRRVGLMCEGAPMRAHSPILNMEGTKIGTVTSGCPSPSLKKNVAMGYVPCEYSRPGTMLLVEVRRKQQMAVVSKMPFVPTNYYTLK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion
Function
- Function:
- The glycine cleavage system catalyzes the degradation of glycine.
- Catalytic Activity:
- -S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = -dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH(3).
- Cross Reference Drug Bank:
- DB00116
- Gene Ontology Go:
- mitochondrial matrix
mitochondrion
aminomethyltransferase activity
transaminase activity
cellular nitrogen compound metabolic process
glycine catabolic process
glyoxylate metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
glycine catabolic process
glyoxylate metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- aminomethyltransferase activity
transaminase activity - Gene Ontology Cellular Component:
- mitochondrial matrix
mitochondrion - Keywords:
- 3D-structure
Alternative splicing
Aminotransferase
Complete proteome
Disease mutation
Mitochondrion
Reference proteome
Transferase
Transit peptide