Names & Taxonomy
- Uniprot ID:
- P48547
- Entry Name:
- KCNC1_HUMAN
- Status:
- reviewed
- Protein Names:
- Potassium voltage-gated channel subfamily C member 1 (NGK2) (Voltage-gated potassium channel subunit Kv3.1) (Voltage-gated potassium channel subunit Kv4)
- Gene Names:
- KCNC1
- Gene Names Primary:
- KCNC1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 511
- Sequence:
- MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTCPLAQEEILEINRAGRKPLRGMSI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons.
- Cross Reference Drug Bank:
- DB06637
- Gene Ontology Go:
- cell surface
dendrite
neuron projection membrane
neuronal cell body membrane
plasma membrane
voltage-gated potassium channel complex
delayed rectifier potassium channel activity
voltage-gated potassium channel activity
cellular response to drug
cerebellum development
globus pallidus development
positive regulation of potassium ion transmembrane transport
potassium ion transmembrane transport
potassium ion transport
protein homooligomerization
protein tetramerization
response to amine
response to auditory stimulus
response to fibroblast growth factor
response to light intensity
response to nerve growth factor
response to potassium ion
response to toxic substance
synaptic transmission - Gene Ontology Biological Process:
- cellular response to drug
cerebellum development
globus pallidus development
positive regulation of potassium ion transmembrane transport
potassium ion transmembrane transport
potassium ion transport
protein homooligomerization
protein tetramerization
response to amine
response to auditory stimulus
response to fibroblast growth factor
response to light intensity
response to nerve growth factor
response to potassium ion
response to toxic substance
synaptic transmission - Gene Ontology Molecular Function:
- delayed rectifier potassium channel activity
voltage-gated potassium channel activity - Gene Ontology Cellular Component:
- cell surface
dendrite
neuronal cell body membrane
neuron projection membrane
plasma membrane
voltage-gated potassium channel complex - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Disease mutation
Epilepsy
Glycoprotein
Ion channel
Ion transport
Membrane
Phosphoprotein
Potassium
Potassium channel
Potassium transport
Reference proteome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel