Names & Taxonomy
- Uniprot ID:
- P43080
- Entry Name:
- GUC1A_HUMAN
- Status:
- reviewed
- Protein Names:
- Guanylyl cyclase-activating protein 1 (GCAP 1) (Guanylate cyclase activator 1A)
- Gene Names:
- GUCA1A C6orf131 GCAP GCAP1 GUCA1
- Gene Names Primary:
- GUCA1A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 201
- Sequence:
- MGNVMEGKSVEELSSTECHQWYKKFMTECPSGQLTLYEFRQFFGLKNLSPSASQYVEQMFETFDFNKDGYIDFMEYVAALSLVLKGKVEQKLRWYFKLYDVDGNGCIDRDELLTIIQAIRAINPCSDTTMTAEEFTDTVFSKIDVNGDGELSLEEFIEGVQKDQMLLDTLTRSLDLTRIVRRLQNGEQDEEGADEAAEAAG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Lipid-anchor.
Function
- Function:
- Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated (PubMed:19459154). This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure.
- Gene Ontology Go:
- photoreceptor disc membrane
photoreceptor inner segment
plasma membrane
calcium ion binding
calcium sensitive guanylate cyclase activator activity
guanylate cyclase regulator activity
cellular response to calcium ion
phototransduction, visible light
positive regulation of guanylate cyclase activity
regulation of rhodopsin mediated signaling pathway
rhodopsin mediated signaling pathway
signal transduction
visual perception - Gene Ontology Biological Process:
- cellular response to calcium ion
phototransduction, visible light
positive regulation of guanylate cyclase activity
regulation of rhodopsin mediated signaling pathway
rhodopsin mediated signaling pathway
signal transduction
visual perception - Gene Ontology Molecular Function:
- calcium ion binding
calcium sensitive guanylate cyclase activator activity
guanylate cyclase regulator activity - Gene Ontology Cellular Component:
- photoreceptor disc membrane
photoreceptor inner segment
plasma membrane - Keywords:
- Calcium
Complete proteome
Disease mutation
Lipoprotein
Membrane
Metal-binding
Myristate
Reference proteome
Repeat
Sensory transduction
Vision