Names & Taxonomy
- Uniprot ID:
- P42336
- Entry Name:
- PK3CA_HUMAN
- Status:
- reviewed
- Protein Names:
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1)
- Gene Names:
- PIK3CA
- Gene Names Primary:
- PIK3CA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1068
- Sequence:
- MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQLLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMDCFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHCPLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
- Proteomes:
- UP000005640
Function
- Function:
- Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Also has serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS. Plays a role in the positive regulation of phagocytosis and pinocytosis (By similarity).
- Catalytic Activity:
- ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
- Cross Reference Drug Bank:
- DB00201
- Gene Ontology Go:
- cytosol
lamellipodium
phosphatidylinositol 3-kinase complex
phosphatidylinositol 3-kinase complex, class IA
plasma membrane
1-phosphatidylinositol-3-kinase activity
1-phosphatidylinositol-4-phosphate 3-kinase activity
ATP binding
kinase activity
phosphatidylinositol 3-kinase activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
protein kinase activator activity
protein serine/threonine kinase activity
adaptive immune response
adipose tissue development
angiogenesis
blood coagulation
cardiac muscle contraction
cell chemotaxis
cellular response to glucose stimulus
endothelial cell migration
energy homeostasis
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
fibroblast growth factor receptor signaling pathway
glucose metabolic process
hypomethylation of CpG island
inflammatory response
innate immune response
insulin receptor signaling pathway
insulin receptor signaling pathway via phosphatidylinositol 3-kinase
leukocyte migration
liver development
mitophagy in response to mitochondrial depolarization
negative regulation of anoikis
negative regulation of fibroblast apoptotic process
negative regulation of neuron apoptotic process
neurotrophin TRK receptor signaling pathway
phosphatidylinositol 3-kinase signaling
phosphatidylinositol biosynthetic process
phosphatidylinositol phosphorylation
phosphatidylinositol-3-phosphate biosynthetic process
phosphatidylinositol-mediated signaling
phospholipid metabolic process
platelet activation
positive regulation of peptidyl-serine phosphorylation
protein kinase B signaling
protein phosphorylation
regulation of cellular respiration
regulation of gene expression
regulation of genetic imprinting
regulation of multicellular organism growth
small molecule metabolic process
T cell costimulation
T cell receptor signaling pathway
vascular endothelial growth factor receptor signaling pathway
vasculature development - Gene Ontology Biological Process:
- adaptive immune response
adipose tissue development
angiogenesis
blood coagulation
cardiac muscle contraction
cell chemotaxis
cellular response to glucose stimulus
endothelial cell migration
energy homeostasis
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
fibroblast growth factor receptor signaling pathway
glucose metabolic process
hypomethylation of CpG island
inflammatory response
innate immune response
insulin receptor signaling pathway
insulin receptor signaling pathway via phosphatidylinositol 3-kinase
leukocyte migration
liver development
mitophagy in response to mitochondrial depolarization
negative regulation of anoikis
negative regulation of fibroblast apoptotic process
negative regulation of neuron apoptotic process
neurotrophin TRK receptor signaling pathway
phosphatidylinositol 3-kinase signaling
phosphatidylinositol-3-phosphate biosynthetic process
phosphatidylinositol biosynthetic process
phosphatidylinositol-mediated signaling
phosphatidylinositol phosphorylation
phospholipid metabolic process
platelet activation
positive regulation of peptidyl-serine phosphorylation
protein kinase B signaling
protein phosphorylation
regulation of cellular respiration
regulation of gene expression
regulation of genetic imprinting
regulation of multicellular organism growth
small molecule metabolic process
T cell costimulation
T cell receptor signaling pathway
vascular endothelial growth factor receptor signaling pathway
vasculature development - Gene Ontology Molecular Function:
- 1-phosphatidylinositol-3-kinase activity
1-phosphatidylinositol-4-phosphate 3-kinase activity
ATP binding
kinase activity
phosphatidylinositol 3-kinase activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
protein kinase activator activity
protein serine/threonine kinase activity - Gene Ontology Cellular Component:
- cytosol
lamellipodium
phosphatidylinositol 3-kinase complex
phosphatidylinositol 3-kinase complex, class IA
plasma membrane - Keywords:
- 3D-structure
ATP-binding
Angiogenesis
Complete proteome
Disease mutation
Kinase
Nucleotide-binding
Phagocytosis
Polymorphism
Proto-oncogene
Reference proteome
Serine/threonine-protein kinase
Transferase - Interacts With:
- P21860; P35568; P27986; Q92569