Names & Taxonomy
- Uniprot ID:
- P41439
- Entry Name:
- FOLR3_HUMAN
- Status:
- reviewed
- Protein Names:
- Folate receptor gamma (FR-gamma) (Folate receptor 3)
- Gene Names:
- FOLR3
- Gene Names Primary:
- FOLR3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 243
- Sequence:
- MAWQMMQLLLLALVTAAGSAQPRSARARTDLLNVCMNAKHHKTQPSPEDELYGQCSPWKKNACCTASTSQELHKDTSRLYNFNWDHCGKMEPTCKRHFIQDSCLYECSPNLGPWIRQVNQSWRKERILNVPLCKEDCERWWEDCRTSYTCKSNWHKGWNWTSGINECPAGALCSTFESYFPTPAALCEGLWSHSFKVSNYSRGSGRCIQMWFDSAQGNPNEEVAKFYAAAMNAGAPSRGIIDS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform Short does not bind folate.
- Cross Reference Drug Bank:
- DB00158
- Gene Ontology Go:
- extracellular region
extrinsic component of membrane
membrane
folic acid binding
folic acid transport - Gene Ontology Biological Process:
- folic acid transport
- Gene Ontology Molecular Function:
- folic acid binding
- Gene Ontology Cellular Component:
- extracellular region
extrinsic component of membrane
membrane - Keywords:
- Alternative splicing
Complete proteome
Disulfide bond
Folate-binding
Glycoprotein
Receptor
Reference proteome
Secreted
Signal