Names & Taxonomy
- Uniprot ID:
- P36888
- Entry Name:
- FLT3_HUMAN
- Status:
- reviewed
- Protein Names:
- Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135)
- Gene Names:
- FLT3 CD135 FLK2 STK1
- Gene Names Primary:
- FLT3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 993
- Sequence:
- MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen. Note=Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation.
Function
- Function:
- Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
- Catalytic Activity:
- ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
- Enzyme Regulation:
- ENZYME REGULATION: Present in an inactive conformation in the absence of bound ligand. FLT3LG binding leads to dimerization and activation by autophosphorylation.
- Active Site:
- ACT_SITE 811 811 Proton acceptor.
- Cross Reference Drug Bank:
- DB09079 DB08901 DB00398 DB01268
- Gene Ontology Go:
- cytosol
endoplasmic reticulum lumen
integral component of plasma membrane
nucleus
protein complex
ATP binding
cytokine receptor activity
protein homodimerization activity
transmembrane receptor protein tyrosine kinase activity
vascular endothelial growth factor-activated receptor activity
B cell differentiation
cellular response to cytokine stimulus
cellular response to glucocorticoid stimulus
common myeloid progenitor cell proliferation
cytokine-mediated signaling pathway
dendritic cell differentiation
hemopoiesis
leukocyte homeostasis
lymphocyte proliferation
myeloid progenitor cell differentiation
organ regeneration
peptidyl-tyrosine phosphorylation
positive regulation of cell proliferation
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
positive regulation of phosphatidylinositol 3-kinase activity
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of tyrosine phosphorylation of STAT protein
pro-B cell differentiation
protein autophosphorylation
regulation of apoptotic process
response to organonitrogen compound
transmembrane receptor protein tyrosine kinase signaling pathway
vascular endothelial growth factor signaling pathway - Gene Ontology Biological Process:
- B cell differentiation
cellular response to cytokine stimulus
cellular response to glucocorticoid stimulus
common myeloid progenitor cell proliferation
cytokine-mediated signaling pathway
dendritic cell differentiation
hemopoiesis
leukocyte homeostasis
lymphocyte proliferation
myeloid progenitor cell differentiation
organ regeneration
peptidyl-tyrosine phosphorylation
positive regulation of cell proliferation
positive regulation of MAPK cascade
positive regulation of MAP kinase activity
positive regulation of phosphatidylinositol 3-kinase activity
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of tyrosine phosphorylation of STAT protein
pro-B cell differentiation
protein autophosphorylation
regulation of apoptotic process
response to organonitrogen compound
transmembrane receptor protein tyrosine kinase signaling pathway
vascular endothelial growth factor signaling pathway - Gene Ontology Molecular Function:
- ATP binding
cytokine receptor activity
protein homodimerization activity
transmembrane receptor protein tyrosine kinase activity
vascular endothelial growth factor-activated receptor activity - Gene Ontology Cellular Component:
- cytosol
endoplasmic reticulum lumen
integral component of plasma membrane
nucleus
protein complex - Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Complete proteome
Disease mutation
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Immunoglobulin domain
Kinase
Membrane
Nucleotide-binding
Phosphoprotein
Polymorphism
Proto-oncogene
Receptor
Reference proteome
Signal
Transferase
Transmembrane
Transmembrane helix
Tyrosine-protein kinase
Ubl conjugation - Interacts With:
- Q9Y6K9; P27986; Q12913; P43405