Names & Taxonomy
- Uniprot ID:
- P35030
- Entry Name:
- TRY3_HUMAN
- Status:
- reviewed
- Protein Names:
- Trypsin-3 (EC 3.4.21.4) (Brain trypsinogen) (Mesotrypsinogen) (Serine protease 3) (Serine protease 4) (Trypsin III) (Trypsin IV)
- Gene Names:
- PRSS3 PRSS4 TRY3 TRY4
- Gene Names Primary:
- PRSS3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 304
- Sequence:
- MCGPDDRCPARWPGPGRAVKCGKGLAAARPGRVERGGAQRGGAGLELHPLLGGRTWRAARDADGCEALGTVAVPFDDDDKIVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARVSTISLPTTPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGFLEGGKDSCQRDSGGPVVCNGQLQGVVSWGHGCAWKNRPGVYTKVYNYVDWIKDTIAANS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5.
- Catalytic Activity:
- Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; ; Note=Binds 1 Ca(2+) ion per subunit.;
- Active Site:
- ACT_SITE 120 120 Charge relay system.; ACT_SITE 164 164 Charge relay system.; ACT_SITE 257 257 Charge relay system.
- Gene Ontology Go:
- extracellular exosome
extracellular region
extracellular space
calcium ion binding
serine-type endopeptidase activity
serine-type peptidase activity
cobalamin metabolic process
digestion
endothelial cell migration
innate immune response
proteolysis
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process
zymogen activation - Gene Ontology Biological Process:
- cobalamin metabolic process
digestion
endothelial cell migration
innate immune response
proteolysis
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process
zymogen activation - Gene Ontology Molecular Function:
- calcium ion binding
serine-type endopeptidase activity
serine-type peptidase activity - Gene Ontology Cellular Component:
- extracellular exosome
extracellular region
extracellular space - Keywords:
- 3D-structure
Alternative splicing
Calcium
Complete proteome
Digestion
Disulfide bond
Hydrolase
Metal-binding
Polymorphism
Protease
Reference proteome
Secreted
Serine protease
Signal
Sulfation
Zymogen