Names & Taxonomy
- Uniprot ID:
- P34896
- Entry Name:
- GLYC_HUMAN
- Status:
- reviewed
- Protein Names:
- Serine hydroxymethyltransferase, cytosolic (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)
- Gene Names:
- SHMT1
- Gene Names Primary:
- SHMT1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 483
- Sequence:
- MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQKVAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGLPDF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Interconversion of serine and glycine (PubMed:8505317, PubMed:24698160).
- Pathway:
- One-carbon metabolism; tetrahydrofolate interconversion.
- Catalytic Activity:
- 5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine.
- Cofactor:
- COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.18 mM for L-serine
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by tetrahydrofolate concentrations above 40 uM.
- Cross Reference Drug Bank:
- DB00145 DB01055 DB00116
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
mitochondrion
nucleus
glycine hydroxymethyltransferase activity
L-allo-threonine aldolase activity
protein homodimerization activity
pyridoxal phosphate binding
serine binding
branched-chain amino acid catabolic process
carnitine biosynthetic process
cellular nitrogen compound metabolic process
cellular response to tetrahydrofolate
dTMP biosynthetic process
folic acid metabolic process
glycine biosynthetic process from serine
glycine metabolic process
L-serine catabolic process
L-serine metabolic process
protein homotetramerization
protein tetramerization
purine nucleobase biosynthetic process
small molecule metabolic process
tetrahydrofolate interconversion
tetrahydrofolate metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Biological Process:
- branched-chain amino acid catabolic process
carnitine biosynthetic process
cellular nitrogen compound metabolic process
cellular response to tetrahydrofolate
dTMP biosynthetic process
folic acid metabolic process
glycine biosynthetic process from serine
glycine metabolic process
L-serine catabolic process
L-serine metabolic process
protein homotetramerization
protein tetramerization
purine nucleobase biosynthetic process
small molecule metabolic process
tetrahydrofolate interconversion
tetrahydrofolate metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Molecular Function:
- glycine hydroxymethyltransferase activity
L-allo-threonine aldolase activity
protein homodimerization activity
pyridoxal phosphate binding
serine binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
mitochondrion
nucleus - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
One-carbon metabolism
Polymorphism
Pyridoxal phosphate
Reference proteome
Transferase - Interacts With:
- P45984; P0DMM9